Targeting p97 to Disrupt Protein Homeostasis in Cancer (Q26740517)

Europe PubMed Central

title

Targeting p97 to Disrupt Protein Homeostasis in Cancer (English)

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author

Rekha Rao

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author name string

Pratikkumar Harsukhbhai Vekaria

1

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Trisha Home

2

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Scott Weir

3

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Frank J Schoenen

4

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Rekha Rao

5

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language of work or name

English

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publication date

2016

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published in

Frontiers in Oncology

1 reference

Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin

volume

6

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page(s)

181

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cites work

1 reference

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7 April 2017

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The crystal structure of murine p97/VCP at 3.6A

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Structure of the AAA ATPase p97

7 April 2017

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Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

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Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

7 April 2017

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

7 April 2017

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HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

7 April 2017

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7 April 2017

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Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

7 April 2017

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Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

7 April 2017

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Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase

7 April 2017

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Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

7 April 2017

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Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

7 April 2017

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ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

7 April 2017

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HDAC6-p97/VCP controlled polyubiquitin chain turnover

7 April 2017

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7 April 2017

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AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation

7 April 2017

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Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47

7 April 2017

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Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

7 April 2017

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Hexamerization of p97-VCP is promoted by ATP binding to the D1 domain and required for ATPase and biological activities

7 April 2017

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ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activity

7 April 2017

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p47 is a cofactor for p97-mediated membrane fusion

7 April 2017

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Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

7 April 2017

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

7 April 2017

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ER stress triggers apoptosis by activating BH3-only protein Bim

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Doa1 targets ubiquitinated substrates for mitochondria-associated degradation

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Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway

28 September 2017

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Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii

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Valosin-containing protein-interacting membrane protein (VIMP) links the endoplasmic reticulum with microtubules in concert with cytoskeleton-linking membrane protein (CLIMP)-63

28 September 2017

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Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains

28 September 2017

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Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

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Ubiquitylation in ERAD: reversing to go forward?

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Going through the motions: The ATPase cycle of p97

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12 December 2020

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p97, a protein coping with multiple identities

1 reference

12 December 2020

Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes.

1 reference

12 December 2020

A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting

1 reference

12 December 2020