Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes. (Q53161512)

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31 March 2020

title

Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes (English)

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31 March 2020

11

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author name string

Lin Gui

1

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31 March 2020

Xiaoyi Zhang

2

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31 March 2020

Kelin Li

3

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31 March 2020

Kevin J Frankowski

4

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31 March 2020

Shan Li

5

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31 March 2020

Daniel E Wong

6

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31 March 2020

Derek R Moen

7

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31 March 2020

Patrick R Porubsky

8

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31 March 2020

Henry J Lin

9

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31 March 2020

Frank J Schoenen

10

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31 March 2020

publication date

4 April 2016

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31 March 2020

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31 March 2020

volume

11

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page(s)

953-957

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issue

9

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

31 March 2020

cites work

1 reference

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Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

21 January 2018

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Molecular perspectives on p97-VCP: progress in understanding its structure and diverse biological functions

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Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

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Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

21 January 2018

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Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase

21 January 2018

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Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation

21 January 2018

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Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants

21 January 2018

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Exome sequencing reveals VCP mutations as a cause of familial ALS

21 January 2018

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Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer

21 January 2018

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UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

21 January 2018

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VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line

21 January 2018

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Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

21 January 2018

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The complexities of p97 function in health and disease

21 January 2018

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Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

21 January 2018

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Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

21 January 2018

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Inhibitors of the AAA+ chaperone p97

21 January 2018

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Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.

21 January 2018

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p97: The cell's molecular purgatory?

21 January 2018

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Cdc48 (p97): a "molecular gearbox" in the ubiquitin pathway?

21 January 2018

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Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation

21 January 2018

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Ubiquitin receptors and ERAD: a network of pathways to the proteasome

21 January 2018

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Evaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex

21 January 2018

1 reference

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Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600036

p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600036

Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600036

VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600036

Altered cofactor regulation with disease-associated p97/VCP mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600036

Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600036

inferred from DOI database lookup

7 January 2021

based on heuristic

A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600036

inferred from DOI database lookup

7 January 2021

based on heuristic

p97, a protein coping with multiple identities

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201600036

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/CMDC.201600036

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27043824%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference