Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum (Q24298901)

Synoviolin 1

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Ubiquitin conjugating enzyme E2 D2

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protein K48-linked ubiquitination

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E3 ubiquitin-protein ligase HRD1 YOL013C

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1

Marjolein Kikkert

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author name string

Ram Doolman

2

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Min Dai

3

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Rachel Avner

4

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Gerco Hassink

5

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Sjaak van Voorden

6

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Swapna Thanedar

7

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Joseph Roitelman

8

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Vincent Chau

9

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Emmanuel Wiertz

Journal of Biological Chemistry

10

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publication date

30 January 2004

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language of work or name

English

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published in

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volume

279

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issue

5

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page(s)

3525-34

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cites work

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Novel Aspects of Degradation of T Cell Receptor Subunits from the Endoplasmic Reticulum (ER) in T Cells: Importance of Oligosaccharide Processing, Ubiquitination, and Proteasome-dependent Removal from ER Membranes

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In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation

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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

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The engagement of Sec61p in the ER dislocation process

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Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

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AAA-ATPase p97/Cdc48p, a Cytosolic Chaperone Required for Endoplasmic Reticulum-Associated Protein Degradation

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

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Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol

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Degradation of a short-lived glycoprotein from the lumen of the endoplasmic reticulum: the role of N-linked glycans and the unfolded protein response

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Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

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Mechanisms underlying ubiquitination

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RING finger proteins: mediators of ubiquitin ligase activity

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The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

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RING for destruction?

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PHD domains and E3 ubiquitin ligases: viruses make the connection

21 January 2018

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Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

21 January 2018

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Der3p/Hrd1p Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Lumenal and Integral Membrane Proteins

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Regulation of the mevalonate pathway

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An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast

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A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes

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The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 January 2018

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

21 January 2018

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Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

21 January 2018

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A regulatory link between ER-associated protein degradation and the unfolded-protein response

21 January 2018

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A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation

21 January 2018

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An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport

21 January 2018

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The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

21 January 2018

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Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells

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The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

21 January 2018

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The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

21 January 2018

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E3 ubiquitin ligase that recognizes sugar chains

21 January 2018

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HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project

21 January 2018

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Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

21 January 2018

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Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

21 January 2018

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Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution

21 January 2018

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Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation

21 January 2018

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A simple method for displaying the hydropathic character of a protein

21 January 2018

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Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation

21 January 2018

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Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant

21 January 2018

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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

21 January 2018

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A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1

21 January 2018

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Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

21 January 2018

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The inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by sterol regulatory element binding protein cleavage-activating protein requires four phenylalanine residues in span 6 of HMG-CoA reductase transmembrane dom

21 January 2018

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19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

21 January 2018

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7 January 2021

inferred from DOI database lookup

Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307453200

7 January 2021

inferred from DOI database lookup

The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M307453200

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1074/JBC.M307453200

1 reference

Consolidated OpenCitations Corpus – April 2017

release_bdv6kkh56rf2jah5r4uw6s7agu

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/bdv6kkh56rf2jah5r4uw6s7agu

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

14593114

1 reference

Consolidated OpenCitations Corpus – April 2017