Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention (Q24563397)

10

Jiri Lukas

0 references

Simon Bekker-Jensen

Simon Bekker-Jensen

5

0 references

Claudia Lukas

Claudia Lukas

1

0 references

Stephen P Jackson

Stephen P Jackson

8

0 references

author name string

Fredrik Melander

2

0 references

Manuel Stucki

3

0 references

Jacob Falck

4

0 references

Michal Goldberg

6

0 references

Yaniv Lerenthal

MDC1 is a mediator of the mammalian DNA damage checkpoint

7

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language of work or name

English

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publication date

7 July 2004

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published in

The EMBO Journal

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volume

23

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page(s)

2674-83

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issue

13

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cites work

1 reference

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NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

24 March 2017

1 reference

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Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

24 March 2017

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Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

24 March 2017

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

24 March 2017

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

24 March 2017

1 reference

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

24 March 2017

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A system for stable expression of short interfering RNAs in mammalian cells

24 March 2017

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53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage

24 March 2017

1 reference

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NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors

24 March 2017

1 reference

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Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

24 March 2017

1 reference

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Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

24 March 2017

1 reference

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MDC1 is required for the intra-S-phase DNA damage checkpoint

24 March 2017

1 reference

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

24 March 2017

1 reference

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NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage

24 March 2017

1 reference

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NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways

24 March 2017

1 reference

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NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

24 March 2017

1 reference

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NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain

24 March 2017

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

24 March 2017

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Substrate specificities and identification of putative substrates of ATM kinase family members

24 March 2017

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24 March 2017

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

7 April 2017

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

7 April 2017

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Requirement of the MRN complex for ATM activation by DNA damage

27 September 2017

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The MRN complex: coordinating and mediating the response to broken chromosomes

27 September 2017

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

27 September 2017

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Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability

27 September 2017

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

27 September 2017

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Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage.

27 September 2017

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

27 September 2017

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DNA damage-dependent nuclear dynamics of the Mre11 complex

27 September 2017

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The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

27 September 2017

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A new method for introducing double-strand breaks into cellular DNA.

27 September 2017

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Radiosensitivity in ataxia-telangiectasia: a new explanation

27 September 2017

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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

27 September 2017

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Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600269

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449779

The cellular response to DNA double-strand breaks: defining the sensors and mediators

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15201865

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7600269

1 reference

1240891

1240891

1 reference

1 reference

1 reference