MdmX is a substrate for the deubiquitinating enzyme USP2a (Q24336863)

Ubiquitin specific peptidase 2

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

protein stabilization

1 reference

GOA release 2020-03-11

author

Nerea Allende-Vega

1 reference

ORCID Public Data File 2021

author name string

N Allende-Vega

1

0 references

A Sparks

2

0 references

D P Lane

3

0 references

M K Saville

Tumour suppression: disruption of HAUSP gene stabilizes p53

4

0 references

language of work or name

English

0 references

publication date

21 January 2010

0 references

published in

Oncogene

0 references

volume

29

0 references

issue

3

0 references

page(s)

432-41

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

MDMX regulation of p53 response to ribosomal stress

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

A dynamic role of HAUSP in the p53-Mdm2 pathway

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

MDM2 interacts with MDMX through their RING finger domains

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Hdmx modulates the outcome of p53 activation in human tumor cells

20 April 2017

1 reference

https://api.crossref.org/works/10.1038/ONC.2009.330

Live or let die: the cell's response to p53

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Cisplatin: mode of cytotoxic action and molecular basis of resistance

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Mdm2 and Mdm4 loss regulates distinct p53 activities

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Cisplatin-induced imbalances in the pattern of chimeric marker gene expression in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Gene structure, alternate splicing, tissue distribution, cellular localization, and developmental expression pattern of mouse deubiquitinating enzyme isoforms Usp2-45 and Usp2-69

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

DNA damage-induced MDMX degradation is mediated by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

p53: oncogene or anti-oncogene?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

MDMX: from bench to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

RNA expression induced by cisplatin in an organ of Corti-derived immortalized cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

The isopeptidase USP2a protects human prostate cancer from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

MDM2 and MDM4: p53 regulators as targets in anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

MDM2 inhibitors for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Inhibition of RNA Polymerase II Transcription in Human Cell Extracts by Cisplatin DNA Damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Comparative study of the p53-mdm2 and p53-MDMX interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Divergent N-terminal sequences of a deubiquitinating enzyme modulate substrate specificity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

Structural basis of ubiquitin recognition by the deubiquitinating protease USP2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.330

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.330

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

4748078

1034463028

0 references

Fatcat ID

release_nvd75xo3p5bhrmfbj6427iycry

0 references

4748078

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference