Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. (Q40170945)

18 September 2017

Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. (English)

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18 September 2017

3

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18 September 2017

Rajesh K Singh

1

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PubMed ID

17301054

18 September 2017

Saravanakumar Iyappan

series ordinal

2

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PubMed ID

17301054

18 September 2017

language of work or name

English

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publication date

14 February 2007

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Journal of Biological Chemistry

18 September 2017

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18 September 2017

282

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18 September 2017

15

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18 September 2017

10901-10907

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Mechanisms underlying ubiquitination

18 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M610879200

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610879200

Modification of proteins by ubiquitin and ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Structure and interactions of the helical and U-box domains of CHIP, the C terminus of HSP70 interacting protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610879200

MDM2 interacts with MDMX through their RING finger domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

MdmX protects p53 from Mdm2-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Involvement of the DNA repair protein hHR23 in p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

DNA damage-induced MDMX degradation is mediated by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

The ubiquitin-protein ligase activity of Hdm2 is inhibited by nucleic acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

Solution Structure of the Hdm2 C2H2C4 RING, a Domain Critical for Ubiquitination of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610879200

21 January 2018

Identifiers

DOI

10.1074/JBC.M610879200

1 reference

18 September 2017

1 reference

PubMed ID

17301054