Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine (Q24323093)

positive regulation of response to DNA damage stimulus

GOA release 2020-03-11

1 reference

Myelocytomatosis oncogene

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Andreas Höglund

1

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Lisa M Nilsson

2

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Linus Plym Forshell

3

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Kirsteen H Maclean

4

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Jonas A Nilsson

Activity of decitabine, a hypomethylating agent, in chronic myelomonocytic leukemia

5

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language of work or name

English

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publication date

30 April 2009

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published in

Blood

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volume

113

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page(s)

4281-8

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issue

18

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cites work

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Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience

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DNA methylation: the nuts and bolts of repression

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Induction of apoptosis in fibroblasts by c-myc protein

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Multistep evolution of B-cell-derived tumors in humans and rodents

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Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling

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7 January 2021

Tumor spectrum analysis in p53-mutant mice

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PUMA, a novel proapoptotic gene, is induced by p53

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Negative regulation of the mammalian UV response by Myc through association with Miz-1

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The RB and p53 pathways in cancer

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Chk1 and Chk2 kinases in checkpoint control and cancer

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Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism.

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Death through a tragedy: mitotic catastrophe

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

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7 January 2021

Epigenetics in human disease and prospects for epigenetic therapy

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Non-transcriptional control of DNA replication by c-Myc

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Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt's lymphoma in children.

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7 January 2021

p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

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Myc pathways provoking cell suicide and cancer

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Suppression of tumorigenesis by the p53 target PUMA

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Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

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p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia

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Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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BUB1 mediation of caspase-independent mitotic death determines cell fate

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Burkitt lymphoma in the mouse.

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Deciphering the cellular functions of the Op18/Stathmin family of microtubule-regulators by plasma membrane-targeted localization.

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7 January 2021

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

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7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

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7 January 2021

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

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7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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7 January 2021

Lytic induction therapy for Epstein-Barr virus-positive B-cell lymphomas

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7 January 2021

Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis

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7 January 2021

DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.

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7 January 2021

c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-XL

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7 January 2021

Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice.

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7 January 2021

The roles of therapy-induced autophagy and necrosis in cancer treatment

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7 January 2021

Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis

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7 January 2021

The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.

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7 January 2021

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

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7 January 2021

The consequences of tetraploidy and aneuploidy

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7 January 2021

c-MYC delays prometaphase by direct transactivation of MAD2 and BubR1: identification of mechanisms underlying c-MYC-induced DNA damage and chromosomal instability

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7 January 2021