Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation (Q35939534)

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English	Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation	scientific article

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scholarly article

1 reference

Europe PubMed Central

11 August 2017

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation (English)

1 reference

Europe PubMed Central

11 August 2017

0 references

Rudolf Jaenisch

3

object named as

R Jaenisch

1 reference

Europe PubMed Central

11 August 2017

author name string

R Jüttermann

1

1 reference

Europe PubMed Central

11 August 2017

E Li

2

1 reference

Europe PubMed Central

11 August 2017

language of work or name

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publication date

1 December 1994

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Europe PubMed Central

11 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

11 August 2017

91

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Europe PubMed Central

11 August 2017

11797-11801

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Europe PubMed Central

11 August 2017

25

1 reference

Europe PubMed Central

11 August 2017

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Activation of an imprinted Igf 2 gene in mouse somatic cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

HhaI methyltransferase flips its target base out of the DNA helix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Role for DNA methylation in genomic imprinting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Parental imprinting of autosomal mammalian genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

5-Aza-2'-deoxycytidine (Decitabine) and 5-azacytidine in the treatment of acute myeloid leukemias and myelodysplastic syndromes: past, present and future trends

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Genomic sequencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

The 5-methylcytosine content of DNA from human tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

DNA modification, differentiation, and transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Altering gene expression with 5-azacytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Simplified mammalian DNA isolation procedure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

2 October 2017

DNA hypomethylation causes an increase in DNase-I sensitivity and an advance in the time of replication of the entire inactive X chromosome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

11 July 2018

5-Azadeoxycytidine induced undercondensation in the giant X chromosomes of Microtus agrestis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

24 September 2018

Induction of differentiation and inhibition of DNA methylation in HL-60 myeloid leukemic cells by 5-AZA-2'-deoxycytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45322

24 September 2018

The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2'-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced genomic 5-methylcytosine content in human colonic neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of 5-aza-2'-deoxycytidine in a mammalian cell system

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preliminary results with 5-aza-2'-deoxycytidine (DAC)-containing chemotherapy in patients with relapsed or refractory acute leukemia. The EORTC Leukemia Cooperative Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arabidopsis thaliana DNA methylation mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased cytosine DNA-methyltransferase activity during colon cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA methylation and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of DNA methylation in L1210 leukemic cells by 5-aza-2'-deoxycytidine as a possible mechanism of chemotherapeutic action

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic study of 5-aza-2'-deoxycytidine (NSC 127716) in cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic and catalytic mechanism of HhaI methyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/7527544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.91.25.11797

1 reference

Europe PubMed Central

11 August 2017

1994PNAS...9111797J

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1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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