Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways (Q24316917)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19625296%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways (English)

1 reference

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3 February 2020

1 reference

Dishevelled segment polarity protein 3

1 reference

Leucine rich repeat kinase 2

1 reference

Dishevelled segment polarity protein 1

1 reference

regulation of protein localization

1 reference

author

Bernard M H Law

series ordinal

2

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3 February 2020

author name string

Rosa M Sancho

series ordinal

1

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3 February 2020

Kirsten Harvey

series ordinal

3

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3 February 2020

language of work or name

English

0 references

publication date

22 July 2009

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3 February 2020

published in

Human Molecular Genetics

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3 February 2020

volume

18

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3 February 2020

issue

20

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3 February 2020

page(s)

3955-3968

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

3 February 2020

cites work

1 reference

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A genomic pathway approach to a complex disease: axon guidance and Parkinson disease

19 March 2017

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

19 March 2017

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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

19 March 2017

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

19 March 2017

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

19 March 2017

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

19 March 2017

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19 March 2017

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Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

19 March 2017

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Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development

19 March 2017

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Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo

19 March 2017

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Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

19 March 2017

1 reference

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GEFs and GAPs: critical elements in the control of small G proteins

19 March 2017

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Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

19 March 2017

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Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release

19 March 2017

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LRRK2 in Parkinson's disease: protein domains and functional insights

19 March 2017

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Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion

19 March 2017

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Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

19 March 2017

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

19 March 2017

1 reference

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

19 March 2017

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Expanded characterization of the social interaction abnormalities in mice lacking Dvl1

19 March 2017

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Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

19 March 2017

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Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure

19 March 2017

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Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease

19 March 2017

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Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1

19 March 2017

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

19 March 2017

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

7 April 2017

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

7 April 2017

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7 April 2017

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Stages in the development of Parkinson's disease-related pathology

7 April 2017

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Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP

7 April 2017

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Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

27 September 2017

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CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

27 September 2017

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FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action.

27 September 2017

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Wnt signaling in neuroprotection and stem cell differentiation

27 September 2017

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RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player

27 September 2017

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The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

27 September 2017

1 reference

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Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

27 September 2017

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c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability

27 September 2017

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Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

27 September 2017

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The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

27 September 2017

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Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death

27 September 2017

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Roc, a Ras/GTPase domain in complex proteins

27 September 2017

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Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism

27 September 2017

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The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

27 September 2017

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Development of a yeast trihybrid screen using stable yeast strains and regulated protein expression.

30 May 2018

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30 May 2018

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Crossref

https://api.crossref.org/works/10.1093%2FHMG%2FDDP337

Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19625296

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDP337

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19625296%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19625296%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

19625296

1 reference