Dishevelled segment polarity protein 1 (Q21116575)

Ubiquitin-like domain superfamily

1 reference

Winged helix-like DNA-binding domain superfamily

1 reference

Dishevelled-1

1 reference

PDZ superfamily

1 reference

DIX domain superfamily

1 reference

DIX domain, protein family

1 reference

Dishevelled

1 reference

PDZ domain, protein family

1 reference

Dishevelled C-terminal domain, protein family

1 reference

DEP domain, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

17 October 2017

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14640&geneProductId=UniProtKB:O14640

19 references

1 January 2018

Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

The Hippo pathway regulates Wnt/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

identical protein binding

IPI

3 references

1 January 2018

A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane

lateral plasma membrane

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

microtubule cytoskeleton

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

clathrin-coated vesicle

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

Schaffer collateral - CA1 synapse

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

glutamatergic synapse

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

regulation of protein phosphorylation

biological process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

negative regulation of protein phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

positive regulation of protein phosphorylation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

intracellular signal transduction

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

negative regulation of protein kinase activity

1 reference

1 January 2018

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

transcription by RNA polymerase II

1 reference

1 January 2018

beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

negative regulation of protein binding

1 reference

1 January 2018

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

positive regulation of Wnt signaling pathway

1 reference

17 October 2017

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14640&geneProductId=UniProtKB:O14640

multicellular organism development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

Wnt signaling pathway, planar cell polarity pathway

3 references

1 January 2018

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

protein localization to microtubule

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

cochlea morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene

neural tube development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

cytoplasmic microtubule organization

IEP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

positive regulation of neuron projection development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

protein localization to nucleus

1 reference

1 January 2018

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

canonical Wnt signaling pathway

IMP

5 references

17 October 2017

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14640&geneProductId=UniProtKB:O14640

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14640&geneProductId=UniProtKB:O14640

17 October 2017

The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14640&geneProductId=UniProtKB:O14640

17 October 2017

Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14640&geneProductId=UniProtKB:O14640

17 October 2017

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14640&geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

skeletal muscle acetylcholine-gated channel clustering

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

convergent extension involved in neural plate elongation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

negative regulation of canonical Wnt signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

1 January 2018

Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

convergent extension involved in organogenesis

IMP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

positive regulation of canonical Wnt signaling pathway

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14640&geneProductId=UniProtKB:O14640

beta-catenin destruction complex disassembly

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

dendritic spine morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

positive regulation of excitatory postsynaptic potential

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 reference

17 October 2017

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14640&geneProductId=UniProtKB:O14640

positive regulation of protein localization to presynapse

1 reference

1 January 2018

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

non-canonical Wnt signaling pathway

1 reference

1 January 2018

A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

canonical Wnt signaling pathway

9 references

1 January 2018

A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

IBA

postsynapse organization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640

regulation of synaptic vesicle exocytosis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14640