PTEN inhibits BMI1 function independently of its phosphatase activity (Q24315949)

2

0 references

Anil Kapoor

3

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Adrian P Rybak

4

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Jason De Melo

5

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Jean-Claude Cutz

6

0 references

Damu Tang

https://scigraph.springernature.com/pub.10.1186/1476-4598-8-98

7

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language of work or name

English

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publication date

2009

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published in

Molecular Cancer

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volume

8

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issue

1

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page(s)

98

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exact match

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cites work

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs

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Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

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PTEN: life as a tumor suppressor

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

7 April 2017

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PIK3CA alterations in Middle Eastern ovarian cancers

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Bmi1 promotes prostate tumorigenesis via inhibiting p16(INK4A) and p14(ARF) expression.

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Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells

27 September 2017

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Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

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The nuclear affairs of PTEN.

27 September 2017

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Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer

27 September 2017

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Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL.

27 September 2017

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Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells

27 September 2017

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p14ARF inhibits the growth of p53 deficient cells in a cell-specific manner

27 September 2017

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Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein

27 September 2017

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Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer

27 September 2017

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Stem cells and cancer; the polycomb connection

27 September 2017

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27 September 2017

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The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins

27 September 2017

1 reference

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The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells

27 September 2017

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PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers

27 September 2017

1 reference

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The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression

27 September 2017

1 reference

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Molecular genetics of prostate cancer.

27 September 2017

1 reference

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777864

E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777864

ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function

30 May 2018

1 reference

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Akt is activated in response to an apoptotic signal.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777864

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

30 May 2018

1 reference

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30 May 2018

1 reference

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Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777864

CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777864

Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777864

Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777864

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777864

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2777864

BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas

29 November 2018

1 reference

12 December 2020

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

1 reference

12 December 2020

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN

1 reference

12 December 2020

Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis

1 reference

12 December 2020

Identifiers

DOI

10.1186/1476-4598-8-98

1 reference

Dimensions Publication ID

1362001

1016335034

0 references

Fatcat ID

release_qfe2j2hdqvedrjmp3vh2ybre34

0 references

1362001

1 reference

1 reference

1 reference