Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells (Q28201183)

GOA release 2020-03-11

Michael W Becker

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Sean J. Morrison

object named as

Sean J Morrison

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author name string

In-kyung Park

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Dalong Qian

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Mark Kiel

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Michael Pihalja

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Irving L Weissman

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Michael F Clarke

Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells

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publication date

15 May 2003

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language of work or name

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423

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issue

6937

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page(s)

302-5

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cites work

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Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression

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Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells

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"Stemness": transcriptional profiling of embryonic and adult stem cells

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Nucleolar Arf sequesters Mdm2 and activates p53

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

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7 January 2021

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

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7 January 2021

Differential gene expression profiling of adult murine hematopoietic stem cells

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

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Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

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7 January 2021

The purification and characterization of fetal liver hematopoietic stem cells.

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Hematopoietic stem cells are uniquely selective in their migratory response to chemokines

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Chromatin silencing and activation by Polycomb and trithorax group proteins

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HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation

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7 January 2021

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

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7 January 2021

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

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7 January 2021

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages

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7 January 2021

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo

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7 January 2021

The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential

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7 January 2021

Defects in hemopoietic stem cell activity in Ikaros mutant mice

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7 January 2021

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

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7 January 2021

Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells

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7 January 2021

Production of high-titer helper-free retroviruses by transient transfection

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

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7 January 2021