Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage (Q24310132)

cellular response to DNA damage stimulus

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

7

Jiri Bartek

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Jiří Lukáš

6

Jiri Lukas

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Pavel Moudrý

1

Pavel Moudry

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Claudia Lukas

Claudia Lukas

2

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Hana Hanzlíková

Hana Hanzlikova

4

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author name string

Pavel Moudry

1

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Libor Macurek

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Zdenek Hodny

The DNA-damage response in human biology and disease

5

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language of work or name

English

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publication date

15 April 2012

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published in

Cell Cycle

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volume

11

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page(s)

1573-82

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issue

8

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cites work

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MDC1 is required for the intra-S-phase DNA damage checkpoint

20 April 2017

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

20 April 2017

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

20 April 2017

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

20 April 2017

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

20 April 2017

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RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

20 April 2017

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E1-L2 activates both ubiquitin and FAT10

20 April 2017

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Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

20 April 2017

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Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

20 April 2017

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

20 April 2017

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

20 April 2017

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

20 April 2017

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More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

20 April 2017

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Chromatin dynamics and the repair of DNA double strand breaks

21 January 2018

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The ubiquitous role of ubiquitin in the DNA damage response

21 January 2018

1 reference

Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.

21 January 2018

1 reference

UBE1L2, a novel E1 enzyme specific for ubiquitin

21 January 2018

1 reference

The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks

21 January 2018

1 reference

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

21 January 2018

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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

21 January 2018

1 reference

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

21 January 2018

1 reference

Replication stress induces 53BP1-containing OPT domains in G1 cells

21 January 2018

1 reference

Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.

21 January 2018

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Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1

21 January 2018

1 reference

Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition

21 January 2018

1 reference

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

21 January 2018

1 reference

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling

21 January 2018

1 reference

DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'.

21 January 2018

1 reference

An oncogene-induced DNA damage model for cancer development

21 January 2018

1 reference

Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations

21 January 2018

1 reference

Unleashing Chk1 in cancer therapy.

21 January 2018

1 reference

Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1.

21 January 2018

1 reference

Cancer proliferation gene discovery through functional genomics.

21 January 2018

1 reference

Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives

21 January 2018

1 reference

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

21 January 2018

1 reference

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).

21 January 2018

1 reference

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling.

21 January 2018

1 reference

Genetic Interactions in Cancer Progression and Treatment

21 January 2018

1 reference