Transformation related protein 53 (Q14818136)

p53-like tetramerisation domain superfamily

1 reference

p53/RUNT-type transcription factor, DNA-binding domain superfamily

1 reference

p53 tumour suppressor family

1 reference

p53 transactivation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

p53, tetramerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

p53, DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein N-terminus binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

DNA-binding transcription factor activity

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

SEI family of nuclear factors regulates p53-dependent transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

DNA-binding transcription activator activity, RNA polymerase II-specific

3 references

11 October 2018

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

11 October 2018

Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

11 October 2018

SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

histone deacetylase regulator activity

1 reference

9 May 2019

A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

protein self-association

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

protein phosphatase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

2 references

transcription factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

protein phosphatase 2A binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

52 references

9 May 2019

Trim24 targets endogenous p53 for degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53 opens the mitochondrial permeability transition pore to trigger necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Trim24 targets endogenous p53 for degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Deletion of Swm2p selectively impairs trimethylation of snRNAs by trimethylguanosine synthase (Tgs1p).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Interaction between transcription factor, basal transcription factor 3, and the NH2-terminal domain of human estrogen receptor alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Naked cuticle targets dishevelled to antagonize Wnt signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Hepatitis C virus core protein interacts with a human DEAD box protein DDX3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Binding and modulation of p53 by p300/CBP coactivators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Design and application of a cytokine-receptor-based interaction trap

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53 opens the mitochondrial permeability transition pore to trigger necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

A Pin1/mutant p53 axis promotes aggressiveness in breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Interaction of Sesbania mosaic virus movement protein with the coat protein--implications for viral spread

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Near-UV cyanobacteriochrome signaling system elicits negative phototaxis in the cyanobacterium Synechocystis sp. PCC 6803

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Structural basis for the molecular evolution of SRP-GTPase activation by protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Interaction of nucleoside diphosphate kinase and catalases for stress and light responses in Neurospora crassa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

BAF60a interacts with p53 to recruit the SWI/SNF complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Negative control of p53 by Sir2alpha promotes cell survival under stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

histone acetyltransferase binding

IPI

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

2 references

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

receptor tyrosine kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

ubiquitin protein ligase binding

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

histone deacetylase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

disordered domain specific binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

RNA polymerase II cis-regulatory region sequence-specific DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

TFIID-class transcription factor complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

transcription coregulator binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

protein C-terminus binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

p53 regulates Period2 expression and the circadian clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

core promoter sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

RNA polymerase II cis-regulatory region sequence-specific DNA binding

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

DNA-binding transcription activator activity, RNA polymerase II-specific

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

ubiquitin protein ligase binding

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

protein homodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

MDM2/MDM4 family protein binding

promoter-specific chromatin binding

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

2 references

14 February 2019

Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53 has a direct apoptogenic role at the mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

15 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

site of double-strand break

1 reference

9 May 2019

PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

transcription factor TFIID complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

2 references

endoplasmic reticulum

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

intracellular anatomical structure

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

transcription regulator complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

3 references

9 May 2019

Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

The EGF-like protein dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of histone deacetylation

1 reference

9 May 2019

A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

T cell differentiation in thymus

1 reference

9 May 2019

Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway

response to salt stress

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

replicative senescence

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of fibroblast apoptotic process

1 reference

9 May 2019

A role for Xrcc2 in the early stages of mouse development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of cardiac muscle cell apoptotic process

1 reference

9 May 2019

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of telomerase activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of glucose catabolic process to lactate via pyruvate

1 reference

9 May 2019

p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

oligodendrocyte apoptotic process

ISS

regulation of mitochondrial membrane permeability involved in apoptotic process

2 references

1 reference

9 May 2019

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

T cell proliferation involved in immune response

1 reference

9 May 2019

Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to DNA damage stimulus

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of neuron apoptotic process

7 references

9 May 2019

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

B cell lineage commitment

1 reference

9 May 2019

Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of reactive oxygen species metabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

p53 regulates Period2 expression and the circadian clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of intrinsic apoptotic signaling pathway by p53 class mediator

IEP

1 reference

9 May 2019

Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

transforming growth factor beta receptor signaling pathway

1 reference

9 May 2019

Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of cell population proliferation

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Mouse tumor model for neurofibromatosis type 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Mouse models of tumor development in neurofibromatosis type 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

4 references

9 May 2019

Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of mitochondrial membrane permeability

1 reference

9 May 2019

p53 opens the mitochondrial permeability transition pore to trigger necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of proteolysis

1 reference

9 May 2019

Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

nucleotide-excision repair

ISS

cellular response to glucose starvation

2 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of transcription, DNA-templated

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity

mitochondrial DNA repair

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of thymocyte apoptotic process

1 reference

9 May 2019

The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

embryonic organ development

1 reference

9 May 2019

PACT is a negative regulator of p53 and essential for cell growth and embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cardiac septum morphogenesis

1 reference

9 May 2019

Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of neuron apoptotic process

1 reference

9 May 2019

Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

in utero embryonic development

4 references

9 May 2019

Female embryonic lethality in mice nullizygous for both Msh2 and p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

No female embryonic lethality in mice nullizygous for Msh2 and p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) background

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of transforming growth factor beta receptor signaling pathway

1 reference

9 May 2019

A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of gene expression

1 reference

9 May 2019

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of neuroblast proliferation

1 reference

9 May 2019

Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of transcription, DNA-templated

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

embryo development ending in birth or egg hatching

1 reference

9 May 2019

ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of mitophagy

1 reference

9 May 2019

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

central nervous system development

1 reference

9 May 2019

Nucleophosmin is required for DNA integrity and p19Arf protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

intrinsic apoptotic signaling pathway by p53 class mediator

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to UV-C

1 reference

9 May 2019

Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to gamma radiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of fibroblast proliferation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Dynamic regulation of p53 subnuclear localization and senescence by MORC3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of intrinsic apoptotic signaling pathway

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

4 references

14 February 2019

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Effects of deficiency in p53 or bcl-2 on the sensitivity of clonogenic cells in the small intestine to low dose-rate irradiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

determination of adult lifespan

1 reference

9 May 2019

Puma is required for p53-induced depletion of adult stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

1 reference

9 May 2019

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

DNA damage response, signal transduction by p53 class mediator

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Nucleophosmin is required for DNA integrity and p19Arf protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

BRCA2 is required for neurogenesis and suppression of medulloblastoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma

protein stabilization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of apoptotic process

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

protein tetramerization

1 reference

9 May 2019

chromosome organization

The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo

cerebellum development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

oxidative stress-induced premature senescence

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

intrinsic apoptotic signaling pathway in response to hypoxia

1 reference

9 May 2019

p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of cellular senescence

1 reference

9 May 2019

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

p53 regulates Period2 expression and the circadian clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of transcription, DNA-templated

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Deacetylation of p53 induces autophagy by suppressing Bmf expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

p53 regulates Period2 expression and the circadian clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

T cell lineage commitment

1 reference

9 May 2019

Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of execution phase of apoptosis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

programmed cell death

1 reference

9 May 2019

regulation of tissue remodeling

1 reference

9 May 2019

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

1 reference

9 May 2019

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of cell population proliferation

3 references

9 May 2019

The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

double-strand break repair

1 reference

9 May 2019

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of protein oligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of apoptotic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

1 reference

9 May 2019

p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of reactive oxygen species metabolic process

1 reference

9 May 2019

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

p53 opens the mitochondrial permeability transition pore to trigger necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

entrainment of circadian clock by photoperiod

1 reference

9 May 2019

p53 regulates Period2 expression and the circadian clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of transcription by RNA polymerase II

11 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

SEI family of nuclear factors regulates p53-dependent transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Repression of p53-dependent sequence-specific transactivation by MEF2c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of mitotic cell cycle

1 reference

9 May 2019

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

transcription by RNA polymerase II

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to UV

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Deacetylation of p53 induces autophagy by suppressing Bmf expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of transcription from RNA polymerase II promoter in response to stress

1 reference

9 May 2019

Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

9 references

14 February 2019

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Puma is required for p53-induced depletion of adult stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

BRCA2 is required for neurogenesis and suppression of medulloblastoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

protein homotetramerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

interferon-gamma-mediated signaling pathway

1 reference

9 May 2019

Deacetylation of p53 induces autophagy by suppressing Bmf expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to ionizing radiation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

14 February 2019

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

signal transduction by p53 class mediator

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to actinomycin D

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of transcription by RNA polymerase II

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of RNA polymerase II transcription preinitiation complex assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

RNA polymerase II preinitiation complex assembly

1 reference

7 November 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

protein-containing complex assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of leukocyte migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to reactive oxygen species

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of cell cycle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of smooth muscle cell proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of intracellular pH

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of hydrogen peroxide-induced cell death

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of DNA biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

regulation of DNA damage response, signal transduction by p53 class mediator

1 reference

9 May 2019

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of production of miRNAs involved in gene silencing by miRNA

1 reference

9 May 2019

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of production of miRNAs involved in gene silencing by miRNA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

RNA polymerase II preinitiation complex assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

programmed necrotic cell death

1 reference

1 January 2018

The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340

positive regulation of programmed necrotic cell death

1 reference

9 May 2019

The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

protein import into nucleus

1 reference

9 May 2019

The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

hematopoietic progenitor cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

nucleotide-excision repair

cellular response to DNA damage stimulus

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

3 references

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

response to oxidative stress

3 references

9 May 2019

Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53 opens the mitochondrial permeability transition pore to trigger necrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

Ras protein signal transduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of cell population proliferation

9 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Mouse tumor model for neurofibromatosis type 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Mouse models of tumor development in neurofibromatosis type 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

5 references

9 May 2019

Effects of deficiency in p53 or bcl-2 on the sensitivity of clonogenic cells in the small intestine to low dose-rate irradiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to inorganic substance

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to metal ion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

3 references

9 May 2019

Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to organonitrogen compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to gamma radiation

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to organic cyclic compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of cell growth

DNA damage response, signal transduction by p53 class mediator

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Nucleophosmin is required for DNA integrity and p19Arf protein stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

BRCA2 is required for neurogenesis and suppression of medulloblastoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

mitotic G1 DNA damage checkpoint signaling

3 references

response to retinoic acid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to vitamin B3

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to heat

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to UV

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Deacetylation of p53 induces autophagy by suppressing Bmf expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

10 references

9 May 2019

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Puma is required for p53-induced depletion of adult stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

BRCA2 is required for neurogenesis and suppression of medulloblastoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of apoptotic process

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of apoptotic process

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to amino acid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of transcription, DNA-templated

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Deacetylation of p53 induces autophagy by suppressing Bmf expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53 regulates Period2 expression and the circadian clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of transcription, DNA-templated

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of transcription by RNA polymerase II

12 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

SEI family of nuclear factors regulates p53-dependent transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Repression of p53-dependent sequence-specific transactivation by MEF2c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to antibiotic

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

negative regulation of fibroblast proliferation

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Integral role of Noxa in p53-mediated apoptotic response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Dynamic regulation of p53 subnuclear localization and senescence by MORC3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

bone marrow development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

response to hyperoxia

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

hematopoietic stem cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to organonitrogen compound

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to hypoxia

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to ionizing radiation

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

cellular response to gamma radiation

intrinsic apoptotic signaling pathway by p53 class mediator

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

9 May 2019

Ribosomal stress induces L11- and p53-dependent apoptosis in mouse pluripotent stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340

positive regulation of release of cytochrome c from mitochondria

oligodendrocyte apoptotic process

positive regulation of intrinsic apoptotic signaling pathway

p53, tetramerisation domain

1 reference

p53 transactivation domain

1 reference

p53, DNA-binding domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016