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tumor protein p53 (Q283350)

From Wikidata
mammalian protein found in Homo sapiens
  • Tumor suppressor p53
  • transformation-related protein 53
  • tumor supressor p53
  • TP53
  • mutant tumor protein 53
  • p53 tumor suppressor
  • antigen NY-CO-13
  • phosphoprotein p53
  • Tumor Suppressor Protein p53
  • cellular tumor antigen p53
  • tumor protein 53
  • p53
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    English
    tumor protein p53
    mammalian protein found in Homo sapiens
    • Tumor suppressor p53
    • transformation-related protein 53
    • tumor supressor p53
    • TP53
    • mutant tumor protein 53
    • p53 tumor suppressor
    • antigen NY-CO-13
    • phosphoprotein p53
    • Tumor Suppressor Protein p53
    • cellular tumor antigen p53
    • tumor protein 53
    • p53

    Statements

    image
    P53.png
    840 × 1,096; 747 KB
    0 references
    has effect
    DNA repair
    0 references
    molecular function
    enzyme binding
    determination method or standard
    IPI
    8 references
    retrieved
    8 April 2019
    stated in
    hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Aprataxin, a novel protein that protects against genotoxic stress
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 modulation of TFIIH–associated nucleotide excision repair activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 is regulated by the lysine demethylase LSD1
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    protein binding
    determination method or standard
    IPI
    310 references
    retrieved
    8 April 2019
    stated in
    MOZ increases p53 acetylation and premature senescence through its complex formation with PML
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Induction of SOX4 by DNA damage is critical for p53 stabilization and function
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RNF125 is a Ubiquitin-Protein Ligase that Promotes p53 Degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ASPP proteins specifically stimulate the apoptotic function of p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Disruption of FAT10-MAD2 binding inhibits tumor progression.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    USP10 regulates p53 localization and stability by deubiquitinating p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular basis of Pirh2-mediated p53 ubiquitylation
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Binding and modulation of p53 by p300/CBP coactivators
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The notch regulator MAML1 interacts with p53 and functions as a coactivator
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Modulation of p53 function by SET8-mediated methylation at lysine 382
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Trim24 targets endogenous p53 for degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Arginine methylation regulates the p53 response
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRD7 is a candidate tumour suppressor gene required for p53 function
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    High mobility group protein-1 (HMG-1) is a unique activator of p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    G9a and Glp methylate lysine 373 in the tumor suppressor p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nucleophosmin regulates the stability and transcriptional activity of p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of p53 tetramerization and nuclear export by ARC
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Repression of p53 activity by Smyd2-mediated methylation
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Critical role for Daxx in regulating Mdm2
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A novel cofactor for p300 that regulates the p53 response
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of p53 activity in nuclear bodies by a specific PML isoform
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 modulation of TFIIH–associated nucleotide excision repair activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Wild-type p53 binds to the TATA-binding protein and represses transcription
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 has a direct apoptogenic role at the mitochondria
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Monoubiquitylation promotes mitochondrial p53 translocation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A Pin1/mutant p53 axis promotes aggressiveness in breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of p53 with the Human Rad51 Protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural features of human histone acetyltransferase p300 and its complex with p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of XIAP translation and induction by MDM2 following irradiation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A human protein-protein interaction network: a resource for annotating the proteome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of differential proteins in nasopharyngeal carcinoma cells with p53 silence by proteome analysis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An Arabidopsis immunophilin, AtFKBP12, binds to AtFIP37 (FKBP interacting protein) in an interaction that is disrupted by FK506
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RYBP stabilizes p53 by modulating MDM2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 Modulates the exonuclease activity of Werner syndrome protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The DNA-binding domain mediates both nuclear and cytosolic functions of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 is regulated by the lysine demethylase LSD1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Trim24 targets endogenous p53 for degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An acetyl-methyl switch drives a conformational change in p53.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRD7 is a candidate tumour suppressor gene required for p53 function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Twist and p53 reciprocally regulate target genes via direct interaction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Evidence for self-association of the alternative sigma factor σ54
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Aurora Kinase-A Inactivates DNA Damage-Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    High mobility group protein-1 (HMG-1) is a unique activator of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Turning the RING domain protein MdmX into an active ubiquitin-protein ligase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Camptothecin induces nuclear export of prohibitin preferentially in transformed cells through a CRM-1-dependent mechanism
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 has a direct apoptogenic role at the mitochondria
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MDM4 binds ligands via a mechanism in which disordered regions become structured
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the p53 C‐terminus bound to 14‐3‐3: Implications for stabilization of the p53 tetramer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Rotavirus-Encoded Nonstructural Protein 1 Modulates Cellular Apoptotic Machinery by Targeting Tumor Suppressor Protein p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inhibition of p53 DNA binding by human papillomavirus E6 proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The yeast two-hybrid system reveals no interaction between p73 alpha and SV40 large T-antigen
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NUMB controls p53 tumour suppressor activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis for the methylation site specificity of SET7/9
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular basis of Pirh2-mediated p53 ubiquitylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis of substrate methylation and inhibition of SMYD2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Towards a proteome-scale map of the human protein–protein interaction network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular recognition of p53 and MDM2 by USP7/HAUSP
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Acetylation is indispensable for p53 activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Synergistic activation of transcription by CBP and p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DBC1 is a negative regulator of SIRT1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Modulation of the vitamin D3 response by cancer-associated mutant p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PACT is a negative regulator of p53 and essential for cell growth and embryonic development
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    S100 proteins interact with the N-terminal domain of MDM2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 opens the mitochondrial permeability transition pore to trigger necrosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nucleophosmin regulates the stability and transcriptional activity of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of p53 tetramerization and nuclear export by ARC
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Viral immune modulators perturb the human molecular network by common and unique strategies
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Negative regulation of p53 functions by Daxx and the involvement of MDM2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Skp2B attenuates p53 function by inhibiting prohibitin
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    AtBAG6, a novel calmodulin-binding protein, induces programmed cell death in yeast and plants
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Critical role for Daxx in regulating Mdm2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TRIAD1 inhibits MDM2‐mediated p53 ubiquitination and degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Role of the translationally controlled tumor protein in DNA damage sensing and repair
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inactivation of the p53 pathway in retinoblastoma.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Activation of p53 Transcriptional Activity by SMRT: a Histone Deacetylase 3-Independent Function of a Transcriptional Corepressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Differential Effect of ik3-1/Cables on p53- and p73-induced Cell Death
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The aberrant expression and localization of prohibitin during apoptosis of human cholangiocarcinoma Mz-ChA-1 cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The central region of HDM2 provides a second binding site for p53.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    S100A4 interacts with p53 in the nucleus and promotes p53 degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TSPYL5 suppresses p53 levels and function by physical interaction with USP7
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mitogen-activated Protein Kinase Kinase 2 (MEK2), a Novel E2-interacting Protein, Promotes the Growth of Classical Swine Fever Virus via Attenuation of the JAK-STAT Signaling Pathway.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction of metallothionein with tumor suppressor p53 protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Aprataxin, a novel protein that protects against genotoxic stress
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A novel cofactor for p300 that regulates the p53 response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Pooled-matrix protein interaction screens using Barcode Fusion Genetics
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 modulates RPA-dependent and RPA-independent WRN helicase activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 Stabilization and accumulation induced by human vaccinia-related kinase 1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of p53 activity through lysine methylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Induction of SOX4 by DNA damage is critical for p53 stabilization and function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ectodermal factor restricts mesoderm differentiation by inhibiting p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Inactivating mutations of acetyltransferase genes in B-cell lymphoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Novel Nucleolar Pathway Connecting Intracellular Energy Status with p53 Activation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Camptothecin-induced downregulation of MLL5 contributes to the activation of tumor suppressor p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of p53 stability and function by the deubiquitinating enzyme USP42
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Negative regulation of the deacetylase SIRT1 by DBC1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 mediates the negative regulation of MDM2 by orphan receptor TR3
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Physical interaction and mutual transrepression between CCAAT/enhancer-binding protein beta and the p53 tumor suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TOE1 interacts with p53 to modulate its transactivation potential
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Modulation of microRNA processing by p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SAFB1 interacts with and suppresses the transcriptional activity of p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    In silico prediction of physical protein interactions and characterization of interactome orphans
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of p53 unbound to T-antigen in human cells transformed by simian virus 40 T-antigen
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A directed protein interaction network for investigating intracellular signal transduction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Repression of p53 activity by Smyd2-mediated methylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b)
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Protein-protein interactions among human lens acidic and basic beta-crystallins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PRAK is essential for ras-induced senescence and tumor suppression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    p53 is regulated by the lysine demethylase LSD1
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Physical and functional interaction between HCV core protein and the different p73 isoforms
    GOA
    curator
    AgBase
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    identical protein binding
    determination method or standard
    IPI
    9 references
    retrieved
    28 February 2017
    stated in
    In silico prediction of physical protein interactions and characterization of interactome orphans
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IPI
    retrieved
    28 February 2017
    stated in
    An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IPI
    retrieved
    28 February 2017
    stated in
    Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IPI
    retrieved
    28 February 2017
    stated in
    Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IPI
    retrieved
    28 February 2017
    stated in
    Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IPI
    retrieved
    28 February 2017
    stated in
    Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IPI
    retrieved
    28 February 2017
    stated in
    Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IPI
    retrieved
    28 February 2017
    stated in
    Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IPI
    retrieved
    28 February 2017
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IPI
    ubiquitin protein ligase binding
    determination method or standard
    IPI
    5 references
    retrieved
    1 January 2018
    stated in
    Identification of a novel gene encoding a p53-associated protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    DNA binding
    determination method or standard
    IDA
    IEA
    IMP
    6 references
    retrieved
    8 April 2019
    stated in
    Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Binding of natively unfolded HIF-1alpha ODD domain to p53
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific
    determination method or standard
    IDA
    ISA
    ISM
    NAS
    6 references
    retrieved
    8 April 2019
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    NAS
    retrieved
    8 April 2019
    stated in
    A census of human transcription factors: function, expression and evolution
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    ISM
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Norwegian University of Science and Technology, Systems Biology team
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    ISA
    retrieved
    8 April 2019
    stated in
    DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phosphorylation of p53 by TAF1 Inactivates p53-Dependent Transcription in the DNA Damage Response
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    identical protein binding
    determination method or standard
    IMP
    IPI
    19 references
    retrieved
    8 April 2019
    stated in
    Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ultraslow oligomerization equilibria of p53 and its implications
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    In silico prediction of physical protein interactions and characterization of interactome orphans
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Core domain interactions in full-length p53 in solution
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Regulation of p53 tetramerization and nuclear export by ARC
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Binding of natively unfolded HIF-1alpha ODD domain to p53
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    ubiquitin protein ligase binding
    determination method or standard
    IEA
    IPI
    6 references
    retrieved
    8 April 2019
    stated in
    CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of a novel gene encoding a p53-associated protein
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    cell component
    cytoplasm
    determination method or standard
    IDA
    IEA
    7 references
    retrieved
    28 February 2017
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IEA
    retrieved
    28 February 2017
    stated in
    USP10 regulates p53 localization and stability by deubiquitinating p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    p53 isoforms can regulate p53 transcriptional activity.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Direct involvement of p53 in programmed cell death of oligodendrocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Regulation of human p53 activity and cell localization by alternative splicing
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    nucleus
    determination method or standard
    IDA
    IEA
    16 references
    retrieved
    28 February 2017
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IEA
    retrieved
    28 February 2017
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IEA
    retrieved
    28 February 2017
    stated in
    HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    USP10 regulates p53 localization and stability by deubiquitinating p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Direct involvement of p53 in programmed cell death of oligodendrocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    p53 isoforms can regulate p53 transcriptional activity.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Myosin VI is a mediator of the p53-dependent cell survival pathway.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Induction of SOX4 by DNA damage is critical for p53 stabilization and function
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Regulation of human p53 activity and cell localization by alternative splicing
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Phosphorylation of p53 by TAF1 Inactivates p53-Dependent Transcription in the DNA Damage Response
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    retrieved
    28 February 2017
    stated in
    Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637
    determination method or standard
    IDA
    nucleus
    determination method or standard
    IDA
    IEA
    IMP
    17 references
    retrieved
    8 April 2019
    stated in
    Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    USP10 regulates p53 localization and stability by deubiquitinating p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Direct involvement of p53 in programmed cell death of oligodendrocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Induction of SOX4 by DNA damage is critical for p53 stabilization and function
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Arginine methylation regulates the p53 response
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Myosin VI is a mediator of the p53-dependent cell survival pathway.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phosphorylation of p53 by TAF1 Inactivates p53-Dependent Transcription in the DNA Damage Response
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    cytoplasm
    determination method or standard
    IDA
    IEA
    IMP
    10 references
    retrieved
    8 April 2019
    stated in
    Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    USP10 regulates p53 localization and stability by deubiquitinating p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Direct involvement of p53 in programmed cell death of oligodendrocytes
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Arginine methylation regulates the p53 response
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    p53 isoforms can regulate p53 transcriptional activity.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Deacetylation of p53 induces autophagy by suppressing Bmf expression
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    biological process
    positive regulation of transcription, DNA-templated
    determination method or standard
    IDA
    IMP
    5 references
    retrieved
    1 January 2018
    stated in
    USP10 regulates p53 localization and stability by deubiquitinating p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    GOA
    curator
    Community Assessment of Community Annotation with Ontologies
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    positive regulation of transcription by RNA polymerase II
    determination method or standard
    IDA
    IGI
    IMP
    10 references
    retrieved
    1 January 2018
    stated in
    Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    1 January 2018
    stated in
    Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IGI
    retrieved
    1 January 2018
    stated in
    DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    1 January 2018
    stated in
    Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
    GOA
    curator
    ARUK-UCL
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    cellular response to DNA damage stimulus
    determination method or standard
    IDA
    IEA
    IMP
    5 references
    retrieved
    8 April 2019
    stated in
    Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
    determination method or standard
    IDA
    IEA
    IMP
    5 references
    retrieved
    8 April 2019
    stated in
    Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    positive regulation of transcription, DNA-templated
    determination method or standard
    IDA
    IEA
    IMP
    6 references
    retrieved
    8 April 2019
    stated in
    USP10 regulates p53 localization and stability by deubiquitinating p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    GOA
    curator
    Community Assessment of Community Annotation with Ontologies
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    positive regulation of transcription by RNA polymerase II
    determination method or standard
    IDA
    IEA
    IGI
    IMP
    11 references
    retrieved
    8 April 2019
    stated in
    Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression
    GOA
    curator
    UniProt
    UniProt protein ID
    P04637
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
    GOA
    curator
    Critical Assessment of Protein Function Annotation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
    GOA
    curator
    ARUK-UCL
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637
    determination method or standard
    IDA
    Commons category
    Tumor suppressor protein p53
    1 reference
    imported from Wikimedia project
    English Wikipedia

    Identifiers

    MeSH descriptor ID
    D016159
    subject named as
    Tumor Suppressor Protein p53
    0 references
    Ensembl protein ID
    HGNC ID
    11998
    0 references
    PDB structure ID
    4ZZJ
    1 reference
    stated in