Bcl-2 and Bax function independently to regulate cell death (Q28591263)

B cell leukemia/lymphoma 2

GOA release 2020-03-11

1 reference

https://scigraph.springernature.com/pub.10.1038/ng0897-358

GOA release 2020-03-11

1 reference

2

S. J. Korsmeyer

1 reference

31 January 2017

C. M. Knudson

1

1 reference

31 January 2017

language of work or name

English

0 references

publication date

1 August 1997

1 reference

31 January 2017

1 reference

31 January 2017

16

1 reference

31 January 2017

358–363

1 reference

31 January 2017

4

1 reference

31 January 2017

0 references

cites work

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

BAX is required for neuronal death after trophic factor deprivation and during development

21 April 2017

1 reference

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 April 2017

1 reference

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 April 2017

1 reference

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

New members of the Bcl-2 family and their protein partners

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Bclx regulates the survival of double-positive thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Bax-independent inhibition of apoptosis by Bcl-XL.

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Social controls on cell survival and cell death

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Protease activation during apoptosis: death by a thousand cuts?

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor.

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Bcl-XL and Bcl-2 repress a common pathway of cell death

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

BID: a novel BH3 domain-only death agonist

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1038%2FNG0897-358

7 January 2021