From discoveries in ageing research to therapeutics for healthy ageing (Q91776870)

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24 April 2020

review article

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title

From discoveries in ageing research to therapeutics for healthy ageing (English)

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24 April 2020

1 reference

1

Judith Campisi

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24 April 2020

3

Gordon J Lithgow

1 reference

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24 April 2020

author name string

Pankaj Kapahi

2

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24 April 2020

Simon Melov

4

1 reference

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24 April 2020

John C Newman

5

1 reference

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24 April 2020

Eric Verdin

6

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24 April 2020

language of work or name

English

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publication date

10 July 2019

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24 April 2020

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24 April 2020

volume

571

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24 April 2020

page(s)

183-192

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24 April 2020

issue

7764

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Caloric restriction improves health and survival of rhesus monkeys

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.

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7 January 2021

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Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

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Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

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7 January 2021

Targeting cellular senescence prevents age-related bone loss in mice.

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7 January 2021

The Clinical Potential of Senolytic Drugs

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7 January 2021

Senolytics improve physical function and increase lifespan in old age

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7 January 2021

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

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Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

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7 January 2021

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Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research

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7 January 2021

Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases

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7 January 2021

Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicity

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7 January 2021

Aging with HIV in the ART era.

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7 January 2021

In search of Methuselah: estimating the upper limits to human longevity

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7 January 2021

Compression of Morbidity Is Observed Across Cohorts with Exceptional Longevity

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7 January 2021

Guiding principles for the care of older adults with multimorbidity: an approach for clinicians: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity

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7 January 2021

Polypharmacy-Time to Get Beyond Numbers

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7 January 2021

Frailty in older adults: evidence for a phenotype

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7 January 2021

Frailty in elderly people

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7 January 2021

Development of a novel frailty index to predict mortality in patients with end-stage liver disease

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7 January 2021

Multidimensional frailty score for the prediction of postoperative mortality risk

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7 January 2021

Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the Rush Memory and Aging Project

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7 January 2021

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

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7 January 2021

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

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7 January 2021

ApoE gene and exceptional longevity: Insights from three independent cohorts.

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7 January 2021

Facing up to the global challenges of ageing

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7 January 2021

SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort.

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7 January 2021

Does caloric restriction extend life in wild mice?

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7 January 2021

Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan

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7 January 2021

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

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7 January 2021

Human genetic individuality

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

MicroRNA predictors of longevity in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Rapamycin Attenuates Age-associated Changes in Tibialis Anterior Tendon Viscoelastic Properties

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Late-life rapamycin treatment reverses age-related heart dysfunction.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Metformin improves healthspan and lifespan in mice

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Frailty as a predictor of surgical outcomes in older patients

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Gait speed and survival in older adults

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Incidence and predictors of multimorbidity in the elderly: a population-based longitudinal study

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Metformin as a Tool to Target Aging

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

TORC1 inhibition enhances immune function and reduces infections in the elderly

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Sirtuin activators and inhibitors: Promises, achievements, and challenges.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55-79 years.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Reduced disability and mortality among aging runners: a 21-year longitudinal study

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Leisure time physical activity of moderate to vigorous intensity and mortality: a large pooled cohort analysis

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Running as a Key Lifestyle Medicine for Longevity

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Can we say what diet is best for health?

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Fasting: molecular mechanisms and clinical applications

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

β-Hydroxybutyrate: A Signaling Metabolite.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Association between advanced age and vascular disease in different arterial territories: a population database of over 3.6 million subjects

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Molecular and phenotypic biomarkers of aging

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

An epigenetic biomarker of aging for lifespan and healthspan.

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

DNA methylation age of human tissues and cell types

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Does accumulation of advanced glycation end products contribute to the aging phenotype?

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

Evidence for a limit to human lifespan

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

The hallmarks of aging

1 reference

https://api.crossref.org/works/10.1038%2FS41586-019-1365-2

7 January 2021

10.1038/S41586-019-1365-2

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31292558%20AND%20SRC:MED&resulttype=core&format=json

24 April 2020

1 reference