Sirtuins: Sir2-related NAD-dependent protein deacetylases (Q21092883)

Dimensions Publication ID

Dimensions

15 August 2022

Brian J North

1

Brian J

North

1 reference

Dimensions Publication ID

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1050900937

https://scigraph.springernature.com/pub.10.1186/gb-2004-5-5-224

15 August 2022

language of work or name

English

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publication date

2004

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28 April 2004

1 reference

28 September 2019

1 reference

28 September 2019

5

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page(s)

224

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issue

5

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exact match

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cites work

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

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Histone deacetylases (HDACs): characterization of the classical HDAC family

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SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

19 March 2017

1 reference

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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

HDAC6 is a microtubule-associated deacetylase

19 March 2017

1 reference

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

19 March 2017

1 reference

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

19 March 2017

1 reference

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Negative control of p53 by Sir2alpha promotes cell survival under stress

19 March 2017

1 reference

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Structure of the histone deacetylase SIRT2

19 March 2017

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Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

19 March 2017

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Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

19 March 2017

1 reference

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

19 March 2017

1 reference

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Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

19 March 2017

1 reference

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

19 March 2017

1 reference

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Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

19 March 2017

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Structure and autoregulation of the yeast Hst2 homolog of Sir2

19 March 2017

1 reference

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Structure of a Sir2 enzyme bound to an acetylated p53 peptide

19 March 2017

1 reference

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Crystal structure of a SIR2 homolog-NAD complex

19 March 2017

1 reference

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

19 March 2017

1 reference

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

19 March 2017

1 reference

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A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast

19 March 2017

1 reference

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Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

19 March 2017

1 reference

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A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

19 March 2017

1 reference

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Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity

19 March 2017

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Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

19 March 2017

1 reference

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The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Identification of a small molecule inhibitor of Sir2p

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Acetylation: a regulatory modification to rival phosphorylation?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

DNA damage activates p53 through a phosphorylation-acetylation cascade

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Extrachromosomal rDNA circles--a cause of aging in yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

An unusual form of transcriptional silencing in yeast ribosomal DNA

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Finding a role for PML in APL pathogenesis: a critical assessment of potential PML activities

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Role of plant polyphenols in genomic stability

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Sir2 links chromatin silencing, metabolism, and aging

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

The conserved core of a human SIR2 homologue functions in yeast silencing

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

cobB function is required for catabolism of propionate in Salmonella typhimurium LT2: evidence for existence of a substitute function for CobB within the 1,2-propanediol utilization (pdu) operon

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Purification and characterization of CobT, the nicotinate-mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase enzyme from Salmonella typhimurium LT2.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

Mechanisms of silencing in Saccharomyces cerevisiae.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

A position effect in the control of transcription at yeast mating type loci.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=416462

A position-effect control for gene transposition: State of expression of yeast mating-type genes affects their ability to switch

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15128440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of NAD(+) in the deacetylase activity of the SIR2-like proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15128440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/GB-2004-5-5-224

1 reference

Dimensions Publication ID

2305350

1050900937

0 references

2305350

1 reference

1 reference

1 reference