Losartan Rescues Inflammation-related Mucociliary Dysfunction in Relevant Models of Cystic Fibrosis (Q90715404)

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15 April 2020

title

Losartan Rescues Inflammation-related Mucociliary Dysfunction in Relevant Models of Cystic Fibrosis (English)

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15 April 2020

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ChEBI release 2020-05-28

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1

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Nathalie Baumlin

2

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Matthias Salathe

15

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author name string

Makoto Yoshida

3

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Deepika Polineni

4

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Sebastian F Salathe

5

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Joseph K David

6

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Charles A Peloquin

7

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Adam Wanner

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John S Dennis

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Juliette Sailland

10

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Philip Whitney

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Frank T Horrigan

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Juan R Sabater

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William M Abraham

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publication date

1 February 2020

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American Journal of Respiratory and Critical Care Medicine

15 April 2020

published in

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volume

201

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15 April 2020

page(s)

313-324

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issue

3

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EXP3174, a metabolite of losartan (MK954, DuP753) is more potent than losartan in blocking the angiotensin ll-induced responses in vascular smooth muscle cells

15 April 2020

cites work

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12 December 2020

TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis

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Mucociliary clearance in cystic fibrosis

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Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.

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End-organ dysfunction in cystic fibrosis: association with angiotensin I converting enzyme and cytokine gene polymorphisms.

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Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease

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Comparative effects of salmeterol, albuterol, and ipratropium on normal and impaired mucociliary function in sheep.

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Mucus clearance and lung function in cystic fibrosis with hypertonic saline.

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12 December 2020

Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway

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12 December 2020

PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression

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12 December 2020

Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells.

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12 December 2020

A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms.

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12 December 2020

Airway surface dehydration in cystic fibrosis: pathogenesis and therapy

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12 December 2020

EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis.

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12 December 2020

Semi-mechanistic modelling of the tumour growth inhibitory effects of LY2157299, a new type I receptor TGF-beta kinase antagonist, in mice

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12 December 2020

Pharmacological Properties of N-(3,5-Diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine Methanesulfonate (552-02), a Novel Epithelial Sodium Channel Blocker with Potential Clinical Efficacy for Cystic Fibrosis L

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12 December 2020

Airway inflammation in cystic fibrosis

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12 December 2020

TMEM16A confers receptor-activated calcium-dependent chloride conductance

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12 December 2020

TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity

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12 December 2020

Expression cloning of TMEM16A as a calcium-activated chloride channel subunit

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12 December 2020

Update on gene modifiers in cystic fibrosis

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12 December 2020

Angiotensin receptor blockers are superior to angiotensin-converting enzyme inhibitors in the suppression of hepatic fibrosis in a bile duct-ligated rat model

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12 December 2020

Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways

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12 December 2020

CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium

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12 December 2020

TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.

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12 December 2020

Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation

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12 December 2020

Transforming growth factor-beta(1) in bronchoalveolar lavage fluid from children with cystic fibrosis.

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12 December 2020

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

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12 December 2020

Losartan normalizes endothelium-derived hyperpolarizing factor-mediated relaxation by activating Ca2+-activated K+ channels in mesenteric artery from type 2 diabetic GK rat.

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12 December 2020

Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode

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12 December 2020

TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells

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12 December 2020

Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia

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12 December 2020

Health care utilization & costs for cystic fibrosis patients with pulmonary infections

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12 December 2020

Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume.

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12 December 2020

Valsartan attenuated oxidative stress, decreased MCP-1 and TGF-β1 expression in glomerular mesangial and epithelial cells induced by high-glucose levels

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12 December 2020

A CFTR potentiator in patients with cystic fibrosis and the G551D mutation

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12 December 2020

Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice

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12 December 2020

Modulation of transforming growth factor-β signaling and extracellular matrix production in myxomatous mitral valves by angiotensin II receptor blockers

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12 December 2020

Tgf-β1 inhibits Cftr biogenesis and prevents functional rescue of ΔF508-Cftr in primary differentiated human bronchial epithelial cells.

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12 December 2020

The role of neutrophils in cystic fibrosis

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12 December 2020

Cystic fibrosis: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases

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12 December 2020

Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure

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12 December 2020

Clinical mechanism of the cystic fibrosis transmembrane conductance regulator potentiator ivacaftor in G551D-mediated cystic fibrosis

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12 December 2020

The angiotensin II type 1 receptor (AT1R) closely interacts with large conductance voltage- and Ca2+-activated K+ (BK) channels and inhibits their activity independent of G-protein activation

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12 December 2020

Tgf-beta downregulation of distinct chloride channels in cystic fibrosis-affected epithelia

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12 December 2020

Atenolol versus losartan in children and young adults with Marfan's syndrome

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12 December 2020

The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis

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12 December 2020

Airway Surface Dehydration by Transforming Growth Factor β (TGF-β) in Cystic Fibrosis Is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone.

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12 December 2020

Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype

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12 December 2020

Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections.

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12 December 2020

Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity

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12 December 2020

SPX-101 is a Novel ENaC-targeted Therapeutic for Cystic Fibrosis that Restores Mucus Transport

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12 December 2020

Airway Mucosal Host Defense is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity

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12 December 2020

Airway Mucin Concentration as a Marker of Chronic Bronchitis

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12 December 2020

Animal and model systems for studying cystic fibrosis

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12 December 2020

VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles

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12 December 2020

10.1164/RCCM.201905-0990OC

Identifiers

DOI

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15 April 2020

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