A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies (Q89777019)

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8 April 2020

title

A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies (English)

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8 April 2020

author name string

Shu-Hui Liu

1

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8 April 2020

Yin Gu

2

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8 April 2020

Bernadette Pascual

3

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8 April 2020

Zhengming Yan

4

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8 April 2020

Max Hallin

5

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8 April 2020

Cathy Zhang

6

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8 April 2020

Conglin Fan

7

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8 April 2020

Wenlian Wang

8

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8 April 2020

Justine Lam

9

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8 April 2020

Mary E Spilker

10

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8 April 2020

Rolla Yafawi

11

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8 April 2020

Eileen Blasi

12

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8 April 2020

Brett Simmons

13

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8 April 2020

Nanni Huser

14

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8 April 2020

Wei-Hsien Ho

15

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8 April 2020

Kevin Lindquist

16

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8 April 2020

Thomas-Toan Tran

17

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8 April 2020

Jyothirmayee Kudaravalli

18

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8 April 2020

Jing-Tyan Ma

19

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8 April 2020

Gretchen Jimenez

20

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8 April 2020

Ishita Barman

21

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8 April 2020

Colleen Brown

22

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8 April 2020

Sherman Michael Chin

23

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8 April 2020

Maria J Costa

24

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8 April 2020

David Shelton

25

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Tod Smeal

26

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8 April 2020

Valeria R Fantin

27

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Flavia Pernasetti

28

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publication date

21 June 2017

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8 April 2020

number of pages

13

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inferred from page(s)

volume

1

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issue

15

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8 April 2020

page(s)

1088-1100

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Genomic organization and promoter characterization of human CXCR4 gene

8 April 2020

cites work

1 reference

12 December 2020

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1 reference

12 December 2020

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

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12 December 2020

Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management

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A systematic overview of chemotherapy effects in acute myeloid leukaemia

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12 December 2020

Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV.

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12 December 2020

Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells

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12 December 2020

Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.

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12 December 2020

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

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12 December 2020

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

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12 December 2020

CXCR4 is a prognostic marker in acute myelogenous leukemia.

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12 December 2020

Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias.

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12 December 2020

Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype

1 reference

12 December 2020

Elevated chemokine receptor CXCR4 expression in primary tumors following neoadjuvant chemotherapy predicts poor outcomes for patients with locally advanced breast cancer (LABC).

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12 December 2020

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

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12 December 2020

CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

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12 December 2020

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.

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12 December 2020

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

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12 December 2020

Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib

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12 December 2020

CXCL12 (SDF-1)/CXCR4 pathway in cancer

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12 December 2020

Leukemia stem cells and microenvironment: biology and therapeutic targeting

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12 December 2020

Advances in the assessment and control of the effector functions of therapeutic antibodies

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12 December 2020

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia

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12 December 2020

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

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Multiple myeloma: treatment evolution

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A review on CXCR4/CXCL12 axis in oncology: no place to hide.

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Innate immunity derived factors as external modulators of the CXCL12-CXCR4 axis and their role in stem cell homing and mobilization

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Dynamic chemotherapy-induced upregulation of CXCR4 expression: a mechanism of therapeutic resistance in pediatric AML.

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12 December 2020

CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia.

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12 December 2020

Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants

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12 December 2020

The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cells in patients with multiple myeloma

1 reference

12 December 2020

Rituximab for non-Hodgkin's lymphoma: a story of rapid success in translation

1 reference

12 December 2020

A phase I trial of LY2510924, a CXCR4 peptide antagonist, in patients with advanced cancer

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12 December 2020

Decreased expression of CXCR4 chemokine receptor in bone marrow after chemotherapy in patients with non-Hodgkin lymphomas is a good prognostic factor

1 reference

12 December 2020

Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models

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Treatment for patients with newly diagnosed multiple myeloma in 2015.

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12 December 2020

Improving chemotherapeutic efficiency in acute myeloid leukemia treatments by chemically synthesized peptide interfering with CXCR4/CXCL12 axis

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12 December 2020

Ulocuplumab (BMS-936564 / MDX1338): a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia mediated through a reactive oxygen species-dependent pathway

1 reference

12 December 2020

10.1182/BLOODADVANCES.2016003921

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29296751%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

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8 April 2020

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