CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. (Q30487339)

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English	CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.	scientific article

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19 January 2020

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy (English)

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19 January 2020

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multiple myeloma

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Kenneth C. Anderson

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Nikhil V Munshi

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Teru Hideshima

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Abdel Kareem Azab

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Feda Azab

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Mena Farag

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Judith M Runnels

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Judith M Runnels

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Molly R Melhem

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Costas M Pitsillides

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Costas Pitsillides

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Anne-Sophie Moreau

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Barrett J Rollins

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Barrett J Rollins

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19 January 2020

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Xiaoying Jia

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19 January 2020

Renee Wright

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19 January 2020

Beatriz Ospina

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Alicia L Carlson

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Clemens Alt

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19 January 2020

Nicholas Burwick

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Hai T Ngo

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19 January 2020

Charles P Lin

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Xavier Leleu

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19 January 2020

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12 January 2009

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19 January 2020

4341-4351

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19 January 2020

describes a project that uses

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Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma

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Role of metalloproteinases MMP-9 and MT1-MMP in CXCL12-promoted myeloma cell invasion across basement membranes

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The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone

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Integrin alpha4beta1 involvement in stromal cell-derived factor-1alpha-promoted myeloma cell transendothelial migration and adhesion: role of cAMP and the actin cytoskeleton in adhesion.

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26 November 2018

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Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications

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Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist

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12 December 2020

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Clinical use of AMD3100 to mobilize CD34+ cells in patients affected by non-Hodgkin's lymphoma or multiple myeloma

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10.1182/BLOOD-2008-10-186668

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19 January 2020

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19 January 2020

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19 January 2020

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