Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers (Q87240112)

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7 March 2020

title

Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers (English)

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7 March 2020

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Tore Bjerregaard Stage

4

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Per Damkier

5

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7 March 2020

Kim Brosen

7

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7 March 2020

author name string

Mette Marie Hougaard Christensen

1

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Kurt Højlund

2

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Ole Hother-Nielsen

3

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Henning Beck-Nielsen

6

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publication date

5 May 2015

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European Journal of Clinical Pharmacology

7 March 2020

published in

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volume

71

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page(s)

691-697

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issue

6

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The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

7 March 2020

cites work

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12 December 2020

Mechanism by which metformin reduces glucose production in type 2 diabetes

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Molecular and functional characteristics of cloned human organic cation transporters.

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Intake of St John's wort improves the glucose tolerance in healthy subjects who ingest metformin compared with metformin alone

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A twin study of the trough plasma steady-state concentration of metformin

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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Transcriptional regulation of murine Slc22a1 (Oct1) by peroxisome proliferator agonist receptor-alpha and -gamma

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Genetic variants of the organic cation transporter 2 influence the disposition of metformin

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Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms

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Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis

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Reduced tubular cation transport in diabetes: prevented by ACE inhibition

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A common 5'-UTR variant in MATE2-K is associated with poor response to metformin

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12 December 2020

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

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12 December 2020

Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic ion transporters, rOAT1, rOAT3 and rOCT2.

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12 December 2020

The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c.

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12 December 2020

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

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Clinical Pharmacokinetics of Metformin

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The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.

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Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

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Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).

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Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin.

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The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha

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12 December 2020

Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients

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12 December 2020

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

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12 December 2020

Pharmacokinetics of metformin after intravenous and oral administration to man

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12 December 2020

Quantitation of metformin in human plasma and urine by hydrophilic interaction liquid chromatography and application to a pharmacokinetic study.

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12 December 2020

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

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12 December 2020

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

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12 December 2020

The SLC22 drug transporter family

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12 December 2020

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

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12 December 2020

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

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12 December 2020

A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin

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12 December 2020

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine

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12 December 2020

Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine

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12 December 2020

Linkage disequilibrium between the CYP2C19*17 allele and other clinically important CYP2C allelic variants in a healthy Scandinavian population

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12 December 2020

Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation

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12 December 2020

Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1

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12 December 2020

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

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12 December 2020

Polyspecific organic cation transporters: their functions and interactions with drugs

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12 December 2020

A New Statistical Method for Haplotype Reconstruction from Population Data

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12 December 2020

Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.

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12 December 2020

Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate

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12 December 2020

Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus

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12 December 2020

Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response

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12 December 2020

10.1007/S00228-015-1853-8

Identifiers

DOI

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7 March 2020

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