Clinical Pharmacokinetics of Metformin (Q22241422)

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20 January 2020

review article

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title

Clinical pharmacokinetics of metformin (English)

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20 January 2020

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4

Richard O Day

Richard O

Day

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20 January 2020

5

Matthew P Doogue

Matthew P

Doogue

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20 January 2020

6

Janna K Duong

Janna K

Duong

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20 January 2020

10

Carl M Kirkpatrick

Carl M

Kirkpatrick

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20 January 2020

Jeroen Punt

2

Jeroen

Punt

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20 January 2020

Manit Arora

3

Manit

Arora

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20 January 2020

Peter Timmins

12

Peter

Timmins

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20 January 2020

Garry G Graham

1

Garry G

Graham

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20 January 2020

Timothy J Furlong

7

Timothy J

Furlong

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20 January 2020

Jerry R Greenfield

8

Jerry R

Greenfield

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20 January 2020

Louise C Greenup

9

Louise C

Greenup

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20 January 2020

John E Ray

11

John E

Ray

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20 January 2020

Kenneth M Williams

13

Kenneth M

Williams

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20 January 2020

language of work or name

English

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publication date

1 February 2011

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Clinical Pharmacokinetics

20 January 2020

published in

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20 January 2020

volume

50

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20 January 2020

page(s)

81-98

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20 January 2020

issue

2

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https://scigraph.springernature.com/pub.10.2165/11534750-000000000-00000

20 January 2020

exact match

0 references

1 reference

12 December 2020

Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: a nested case-control analysis.

1 reference

12 December 2020

Subcellular distribution of metformin in rat liver

1 reference

12 December 2020

Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus

1 reference

12 December 2020

The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

1 reference

12 December 2020

The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.

1 reference

12 December 2020

Global Guideline for Type 2 Diabetes: recommendations for standard, comprehensive, and minimal care.

1 reference

12 December 2020

Antihyperglycaemic efficacy, response prediction and dose-response relations of treatment with metformin and sulphonylurea, alone and in primary combination.

1 reference

12 December 2020

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

1 reference

12 December 2020

Lactic acidosis in metformin therapy: searching for a link with metformin in reports of 'metformin-associated lactic acidosis'.

1 reference

12 December 2020

[Absorption, distribution in the organism and elimination of metformin]

1 reference

12 December 2020

Current understanding of the pharmacogenomics of metformin.

1 reference

12 December 2020

Disposition of metformin (N,N-dimethylbiguanide) in man.

1 reference

12 December 2020

Genetic variants of the organic cation transporter 2 influence the disposition of metformin

1 reference

12 December 2020

Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program

1 reference

12 December 2020

The case. A suicidal woman with delayed high anion gap metabolic acidosis

1 reference

12 December 2020

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms

1 reference

12 December 2020

Metformin kinetics in healthy subjects and in patients with diabetes mellitus

1 reference

12 December 2020

Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity

1 reference

12 December 2020

Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity

1 reference

12 December 2020

Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters

1 reference

12 December 2020

A human transporter protein that mediates the final excretion step for toxic organic cations

1 reference

12 December 2020

Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney.

1 reference

12 December 2020

Pharmacokinetics and bioavailability of a metformin/glyburide tablet administered alone and with food

1 reference

12 December 2020

Metformin and the intestine

1 reference

12 December 2020

Effect of altered gastric emptying and gastrointestinal motility on metformin absorption

1 reference

12 December 2020

Effect of Cephalexin on the Pharmacokinetics of Metformin in Healthy Human Volunteers

1 reference

12 December 2020

Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).

1 reference

12 December 2020

Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences

1 reference

12 December 2020

A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes

1 reference

12 December 2020

A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with metformin, pioglitazone and fenofibrate in healthy subjects

1 reference

12 December 2020

Effect of pregnancy on the pharmacokinetics of metformin

1 reference

12 December 2020

Severe lactic acidosis treated with prolonged hemodialysis: recovery after massive overdoses of metformin

1 reference

12 December 2020

Carrier-mediated transport of metformin across the human placenta determined by using the ex vivo perfusion of the placental cotyledon model

1 reference

12 December 2020

Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine

1 reference

12 December 2020

Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds

1 reference

12 December 2020

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

1 reference

12 December 2020

Pharmacokinetics of metformin after intravenous and oral administration to man

1 reference

12 December 2020

Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man.

1 reference

12 December 2020

Steady-state pharmacokinetics of a novel extended-release metformin formulation

1 reference

12 December 2020

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin

1 reference

12 December 2020

Survival Following a Metformin Overdose of 63 g: A Case Report

1 reference

12 December 2020

Pharmacokinetics and dose proportionality of extended-release metformin following administration of 1000, 1500, 2000 and 2500 mg in healthy volunteers

1 reference

12 December 2020

Investigation of the pharmacokinetic and pharmacodynamic interactions between memantine and glyburide/metformin in healthy young subjects: a single-center, multiple-dose, open-label study

1 reference

12 December 2020

Simultaneous determination of metformin and rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: application to a pharmacokinetic study

1 reference

12 December 2020

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

1 reference

12 December 2020

Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin

1 reference

12 December 2020

Transfer of metformin into human milk

1 reference

12 December 2020

Organic cation transporter 1 polymorphisms predict the metabolic response to metformin in women with the polycystic ovary syndrome

1 reference

12 December 2020

Oral antidiabetic drugs: effect of food on absorption of pioglitazone and metformin from a fixed-dose combination tablet

1 reference

12 December 2020

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

1 reference

12 December 2020

Benefits and Risks of Oral Diabetes Agents Compared With Insulin in Women With Gestational Diabetes

1 reference

12 December 2020

Pharmacokinetics of metformin during pregnancy

1 reference

12 December 2020

Diurnal pattern of plasma metformin concentrations and its relation to metabolic effects in type 2 (non-insulin-dependent) diabetic patients.

1 reference

12 December 2020

A pharmacological method of measuring mouth caecal transit time in man

1 reference

12 December 2020

Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

1 reference

12 December 2020

Prediction of creatinine clearance from serum creatinine

1 reference

12 December 2020

Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations

1 reference

12 December 2020

Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes.

1 reference

12 December 2020

The effect of the ingestion of Ginkgo biloba extract (EGb 761) on the pharmacokinetics of metformin in non-diabetic and type 2 diabetic subjects--a double blind placebo-controlled, crossover study.

1 reference

12 December 2020

Effect of food on the pharmacokinetics of a vildagliptin/metformin (50/1000 mg) fixed-dose combination tablet in healthy volunteers

1 reference

12 December 2020

Reduction of metformin renal tubular secretion by cimetidine in man

1 reference

12 December 2020

Comparative tolerability profiles of oral antidiabetic agents

1 reference

12 December 2020

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

1 reference

12 December 2020

A risk-benefit assessment of metformin in type 2 diabetes mellitus

1 reference

12 December 2020

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study

1 reference

12 December 2020

Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus

1 reference

12 December 2020

Study of the pharmacokinetic interaction of vildagliptin and metformin in patients with type 2 diabetes

1 reference

12 December 2020

Efficacy, tolerability, and safety of a novel once-daily extended-release metformin in patients with type 2 diabetes.

1 reference

12 December 2020

Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjects

1 reference

12 December 2020

Metformin versus insulin for the treatment of gestational diabetes

1 reference

12 December 2020

Variability in renal clearance of substrates for renal transporters in chinese subjects

1 reference

12 December 2020

Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations

1 reference

12 December 2020

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine

1 reference

12 December 2020

Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine

1 reference

12 December 2020

Rosiglitazone does not alter the pharmacokinetics of metformin.

1 reference

12 December 2020

Population exposure-response modeling of metformin in patients with type 2 diabetes mellitus

1 reference

12 December 2020

Metformin use and diabetic pregnancy-has its time come?

1 reference

12 December 2020

Population pharmacokinetics of metformin in late pregnancy

1 reference

12 December 2020

Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations

1 reference

12 December 2020

Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.

1 reference

12 December 2020

Importance of the intestine as a site of metformin-stimulated glucose utilization

1 reference

12 December 2020

A standard approach to compiling clinical pharmacokinetic data

1 reference

12 December 2020

Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

1 reference

12 December 2020

Kidney function and age are both predictors of pharmacokinetics of metformin.

1 reference

12 December 2020

Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2).

1 reference

12 December 2020

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

1 reference

12 December 2020

Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus

1 reference

12 December 2020

Mechanisms underlying saturable intestinal absorption of metformin

1 reference

12 December 2020

Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response

1 reference

12 December 2020

Reality of severe metformin-induced lactic acidosis in the absence of chronic renal impairment.

1 reference

12 December 2020

Measurement of the renal clearance of drugs

1 reference

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7 January 2021

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Identifiers

DOI

10.2165/11534750-000000000-00000

2 references

Consolidated OpenCitations Corpus – April 2017

1425986

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21241070%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 January 2020

1047449776

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1425986

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

1425986