A quantitative framework and strategies for management and evaluation of metabolic drug-drug interactions in oncology drug development: new molecular entities as object drugs (Q85159440)

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scientific article published on 01 November 2010

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English	A quantitative framework and strategies for management and evaluation of metabolic drug-drug interactions in oncology drug development: new molecular entities as object drugs	scientific article published on 01 November 2010

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15 February 2020

A quantitative framework and strategies for management and evaluation of metabolic drug-drug interactions in oncology drug development: new molecular entities as object drugs (English)

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15 February 2020

drug interaction

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Lisa L. von Moltke

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object named as

Lisa L von Moltke

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Karthik Venkatakrishnan

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15 February 2020

Michael D Pickard

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1 November 2010

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15 February 2020

Clinical Pharmacokinetics

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703-727

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15 February 2020

https://scigraph.springernature.com/pub.10.2165/11536740-000000000-00000

0 references

A proposal for a pharmacokinetic interaction significance classification system (PISCS) based on predicted drug exposure changes and its potential application to alert classifications in product labelling

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Apparent high CYP3A5 expression is required for significant metabolism of vincristine by human cryopreserved hepatocytes

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Use of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors.

1 reference

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Impact of ignoring extraction ratio when predicting drug-drug interactions, fraction metabolized, and intestinal first-pass contribution

1 reference

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Genetic variability in CYP3A5 and its possible consequences.

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Predicting drug disposition via application of a Biopharmaceutics Drug Disposition Classification System

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Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans

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General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information

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Impact of parallel pathways of drug elimination and multiple cytochrome P450 involvement on drug-drug interactions: CYP2D6 paradigm.

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A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data

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Drug interactions evaluation: an integrated part of risk assessment of therapeutics

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Selective metabolism of vincristine in vitro by CYP3A5.

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In vitro-in vivo correlation of hepatobiliary drug clearance in humans.

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Effects of Temafloxacin and Ciprofloxacin on the Pharmacokinetics of Caffeine†

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Effect of cytochrome P450 3A4 inhibition on the pharmacokinetics of docetaxel

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Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam

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A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recogn

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Preirradiation paclitaxel in glioblastoma multiforme: efficacy, pharmacology, and drug interactions. New Approaches to Brain Tumor Therapy Central Nervous System Consortium

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Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

1 reference

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Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes

1 reference

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Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

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The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potentia

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The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective.

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Drug interaction studies: study design, data analysis, and implications for dosing and labeling

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Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism

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Cytochrome P450 reaction-phenotyping: an industrial perspective

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The role of ethnicity in variability in response to drugs: focus on clinical pharmacology studies

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Ciprofloxacin greatly increases concentrations and hypotensive effect of tizanidine by inhibiting its cytochrome P450 1A2-mediated presystemic metabolism

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New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process

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So many studies, too few subjects: establishing functional relevance of genetic polymorphisms on pharmacokinetics

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Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations

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Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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'In silico' simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

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Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions

1 reference

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Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects

1 reference

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based on heuristic

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Effect of race on vincristine-associated neurotoxicity in pediatric acute lymphoblastic leukemia patients

1 reference

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Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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12 December 2020

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Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. II. In vitro-in vivo correlation with ketoconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

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1 reference

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12 December 2020

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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12 December 2020

based on heuristic

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1 reference

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12 December 2020

based on heuristic

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Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs.

1 reference

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12 December 2020

based on heuristic

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Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study

1 reference

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1 reference

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1 reference

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12 December 2020

based on heuristic

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1 reference

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12 December 2020

based on heuristic

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1 reference

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12 December 2020

based on heuristic

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Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/20923246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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