Limited influence of UGT1A128 and no effect of UGT2B72 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes (Q36102590)

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Language	Label	Description	Also known as
English	Limited influence of UGT1A128 and no effect of UGT2B72 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

12 August 2017

Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes (English)

1 reference

Europe PubMed Central

12 August 2017

author name string

Vincent C Peterkin

1

1 reference

Europe PubMed Central

12 August 2017

Jonathan N Bauman

2

1 reference

Europe PubMed Central

12 August 2017

Theunis C Goosen

3

1 reference

Europe PubMed Central

12 August 2017

Lee Menning

4

1 reference

Europe PubMed Central

12 August 2017

Michael Z Man

5

1 reference

Europe PubMed Central

12 August 2017

Joseph D Paulauskis

6

1 reference

Europe PubMed Central

12 August 2017

J Andrew Williams

7

1 reference

Europe PubMed Central

12 August 2017

Scott P Myrand

8

1 reference

Europe PubMed Central

12 August 2017

language of work or name

0 references

publication date

6 June 2007

1 reference

Europe PubMed Central

12 August 2017

British Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

12 August 2017

64

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Europe PubMed Central

12 August 2017

4

1 reference

Europe PubMed Central

12 August 2017

458-468

1 reference

Europe PubMed Central

12 August 2017

In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

So many studies, too few subjects: establishing functional relevance of genetic polymorphisms on pharmacokinetics

1 reference

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2 October 2017

Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estradiol and estrone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

UDP-glucuronosyltransferases and clinical drug-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

Genetic variation of human UDP-glucuronosyltransferase: implications in disease and drug glucuronidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 October 2017

Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

2 July 2018

Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

23 September 2018

Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

23 September 2018

Correlation between the UDP-glucuronosyltransferase (UGT1A1) TATAA box polymorphism and carcinogen detoxification phenotype: significantly decreased glucuronidating activity against benzo(a)pyrene-7,8-dihydrodiol(-) in liver microsomes from subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

23 September 2018

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

23 September 2018

A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

23 September 2018

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

23 September 2018

Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2048551

23 September 2018

UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/17555467

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17555467

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER

1 reference

https://pubmed.ncbi.nlm.nih.gov/17555467

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17555467

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human variability in glucuronidation in relation to uncertainty factors for risk assessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17555467

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UDP glucuronosyltransferase mRNA levels in human liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17555467

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17555467

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.2007.02923.X

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

ResearchGate publication ID

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