Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations (Q36985079)

17 August 2017

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title

Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations (English)

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17 August 2017

Hewitt NJ

1

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17 August 2017

Lecluyse EL

series ordinal

2

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17 August 2017

Ferguson SS

series ordinal

3

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17 August 2017

language of work or name

English

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publication date

1 October 2007

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17 August 2017

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17 August 2017

37

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17 August 2017

10-11

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17 August 2017

1196-1224

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Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

17 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Structure-dependent induction of CYP2B by polychlorinated biphenyl congeners in female Sprague-Dawley rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Species difference among experimental rodents in induction of P450IA family enzymes by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Troglitazone induces CYP3A4 activity leading to falsely abnormal dexamethasone suppression test

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Physiological, pharmacological and clinical features of the multidrug resistance protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Cryopreserved human hepatocytes as alternative in vitro model for cytochrome p450 induction studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry--do they comply with FDA recommendations?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Phase I and II enzyme characterization of two sources of HepG2 cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Topical pharmacology of imidazole antifungals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Drug-activated nuclear receptors CAR and PXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Enzyme induction in cryopreserved human hepatocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Regulation of hepatic transporters by xenobiotic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Plasma clearance of lovastatin versus chinese red yeast rice in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

CYP induction-mediated drug interactions: in vitro assessment and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Complexities of glucuronidation affecting in vitro in vivo extrapolation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Lack of effect of type II diabetes on the pharmacokinetics of troglitazone in a multiple-dose study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Hyperforin in St. John's wort drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

A limited sampling method for the estimation of AUC and Cmax of carbamazepine and carbamazepine epoxide following a single and multiple dose of a sustained-release product

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Regulation of subcellular localization of the aryl hydrocarbon receptor (AhR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Time-dependent CYP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Hepatobiliary transport of bile acids and organic anions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Pharmacokinetics of rosiglitazone in patients with end-stage renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Formulation dependent pharmacokinetics--does the dosage form matter for nifedipine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential--toward a consensus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Effects of cell culture conditions on primary rat hepatocytes-cell morphology and differential gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Role of metabolism in drug-induced idiosyncratic hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolemia and hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Induction of CYP2B1 and 3A1, and associated monoxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Induction of phase I, II and III drug metabolism/transport by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Xenobiotic nuclear receptor-mediated regulation of UDP-glucuronosyl-transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Cytochromes P450 and experimental models of drug metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Effects of type of smoking (pipe, cigars or cigarettes) on biological indices of tobacco exposure and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Induced CYP1A2 Activity as a Phenotypic Biomarker in Humans Highly Exposed to Certain PCBs/PCDFs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

Re-expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250701534893

10.1080/00498250701534893

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference