Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome? (Q84008571)

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30 January 2020

title

Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21533018%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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Kendra K Bence

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21533018%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

publication date

1 May 2010

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30 January 2020

volume

1

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30 January 2020

issue

1

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30 January 2020

page(s)

27-33

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TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

30 January 2020

cites work

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12 December 2020

Critical nodes in signalling pathways: insights into insulin action

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12 December 2020

Protein tyrosine phosphatases: prospects for therapeutics

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12 December 2020

Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice

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12 December 2020

Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes

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12 December 2020

Coordinated action of protein tyrosine phosphatases in insulin signal transduction

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12 December 2020

Dissecting the role of insulin resistance in the metabolic syndrome

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12 December 2020

Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

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12 December 2020

Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects

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12 December 2020

Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population

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12 December 2020

The insulin signalling pathway

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12 December 2020

Leptin but not ciliary neurotrophic factor (CNTF) induces phosphotyrosine phosphatase-1B expression in human neuronal cells (SH-SY5Y): putative explanation of CNTF efficacy in leptin-resistant state

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12 December 2020

Adipokines: therapeutic targets for metabolic syndrome

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12 December 2020

Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies

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12 December 2020

Leptin increases hepatic insulin sensitivity and protein tyrosine phosphatase 1B expression

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12 December 2020

A trip to the ER: coping with stress

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12 December 2020

Modulation of insulin activities by leptin

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12 December 2020

Targeting protein tyrosine phosphatase to enhance insulin action for the potential treatment of diabetes.

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12 December 2020

Inhibitors of protein tyrosine phosphatases: next-generation drugs?

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12 December 2020

In vivo and in vitro evidence for a hepatic modulation of the leptin signal in rats.

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12 December 2020

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver

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12 December 2020

The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population.

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12 December 2020

Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action

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12 December 2020

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

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12 December 2020

PTP1B regulates leptin signal transduction in vivo

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12 December 2020

Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance

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12 December 2020

Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice

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12 December 2020

Differential effects of leptin in regulation of tissue glucose utilization in vivo

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12 December 2020

Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis

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12 December 2020

Hepatic insulin resistance directly promotes formation of cholesterol gallstones

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12 December 2020

Selective deletion of leptin receptor in neurons leads to obesity

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12 December 2020

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

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12 December 2020

The use of protein tyrosine phosphatase 1B and insulin receptor immunostains to differentiate nonalcoholic from alcoholic steatohepatitis in liver biopsy specimens

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12 December 2020

Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts

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12 December 2020

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis

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12 December 2020

Alterations in specific protein-tyrosine phosphatases accompany insulin resistance of streptozotocin diabetes

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12 December 2020

Insulin resistance: a metabolic pathway to chronic liver disease

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12 December 2020

Hepatic leptin signaling in obesity.

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12 December 2020

High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice

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12 December 2020

Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway

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12 December 2020

Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance

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12 December 2020

Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress

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12 December 2020

A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro

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12 December 2020

Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population

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12 December 2020

Glucose enhances protein tyrosine phosphatase 1B gene transcription in hepatocytes

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12 December 2020

Signal integration in the endoplasmic reticulum unfolded protein response

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12 December 2020

PTP1B as a drug target: recent developments in PTP1B inhibitor discovery

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12 December 2020

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

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12 December 2020

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

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12 December 2020

Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver

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12 December 2020

Tyrosine phosphatase 1B and leptin receptor genes and their interaction in type 2 diabetes

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12 December 2020

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress

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12 December 2020

Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats

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12 December 2020

Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer

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12 December 2020

Regulation of gene expression by insulin

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12 December 2020

PTP1B: from the sidelines to the front lines!

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12 December 2020

Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling

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12 December 2020

Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes

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12 December 2020

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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12 December 2020

Endoplasmic reticulum (ER) stress & diabetes.

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12 December 2020

Insulin resistance--a common link between type 2 diabetes and cardiovascular disease

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12 December 2020

Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

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12 December 2020

Insulin signaling in health and disease

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12 December 2020

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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12 December 2020

Modulation of insulin signaling by protein tyrosine phosphatases.

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12 December 2020

Therapy of NAFLD: insulin sensitizing agents

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12 December 2020

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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12 December 2020

Regulation of growth factor-induced signaling by protein-tyrosine-phosphatases

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12 December 2020

Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression

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12 December 2020

Novel concepts in insulin regulation of hepatic gluconeogenesis

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12 December 2020

Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance

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12 December 2020

Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein-tyrosine phosphatases in adipose tissue

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12 December 2020

Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects

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12 December 2020

Induction of leptin receptor expression in the liver by leptin and food deprivation

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12 December 2020

Protein tyrosine phosphatase 1B: a novel target for type 2 diabetes and obesity

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12 December 2020

PTP1B inhibitors as potential therapeutics in the treatment of type 2 diabetes and obesity

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12 December 2020

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

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12 December 2020

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

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12 December 2020

ER stress: can the liver cope?

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12 December 2020

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

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12 December 2020

Prodrug delivery of novel PTP1B inhibitors to enhance insulin signalling

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12 December 2020

A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree

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12 December 2020

Metabolic syndrome and cardiovascular disease: challenges and opportunities

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12 December 2020

1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population.

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12 December 2020

Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction

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12 December 2020

A variation in 3' UTR of hPTP1B increases specific gene expression and associates with insulin resistance

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12 December 2020

Leptin, obesity, and liver disease

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12 December 2020

Marked impairment of protein tyrosine phosphatase 1B activity in adipose tissue of obese subjects with and without type 2 diabetes mellitus

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12 December 2020

Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity

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12 December 2020

The insulin signalling system and the IRS proteins

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12 December 2020

Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice

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12 December 2020

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

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12 December 2020

Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

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12 December 2020

Hepatic insulin resistance, metabolic syndrome and cardiovascular disease

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12 December 2020

Neuronal PTP1B regulates body weight, adiposity and leptin action.

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12 December 2020

PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.

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12 December 2020

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

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12 December 2020

Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo

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12 December 2020

Cellular mechanisms of insulin resistance

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12 December 2020

The twentieth century struggle to decipher insulin signalling

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12 December 2020

Analysis of paradoxical observations on the association between leptin and insulin resistance

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12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

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12 December 2020

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21533018%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

21533018

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