Novel concepts in insulin regulation of hepatic gluconeogenesis (Q35213690)

7 August 2017

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title

Novel concepts in insulin regulation of hepatic gluconeogenesis (English)

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7 August 2017

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hepatic gluconeogenesis

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Andreas Barthel

1

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PubMed ID

12959935

7 August 2017

Dieter Schmoll

series ordinal

2

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7 August 2017

1 October 2003

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American Journal of Physiology - Endocrinology and Metabolism

7 August 2017

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7 August 2017

285

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7 August 2017

E685-92

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7 August 2017

4

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Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription

7 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

The Transcription Factor CCAAT/Enhancer-binding Protein β Regulates Gluconeogenesis and Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription during Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Regulation of the Forkhead Transcription Factor FKHR (FOXO1a) by Glucose Starvation and AICAR, an Activator of AMP-Activated Protein Kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Intracellular signalling: PDK1--a kinase at the hub of things

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Role of CBP/P300 in nuclear receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

21 January 2018

The renaissance of GSK3

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Glycogen synthase kinase 3: an emerging therapeutic target

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Mechanism by which metformin reduces glucose production in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

The insulin signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Intrahepatic mechanisms underlying the effect of metformin in decreasing basal glucose production in rats fed a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

The signal-dependent coactivator CBP is a nuclear target for pp90RSK

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Regulation of glucose production by the liver

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Insulin-regulated gene expression

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Insulin signalling and the regulation of glucose and lipid metabolism

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Insulin signaling pathways in time and space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Cellular mechanisms of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Mammalian AMP-activated protein kinase subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Metabolic effects of metformin in non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

An mRNA splice variant of the AFX gene with altered transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Activation of the Ras Mitogen-activated Protein Kinase-Ribosomal Protein Kinase Pathway Is Not Required for the Repression of Phosphoenolpyruvate Carboxykinase Gene Transcription by Insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00253.2003

10.1152/AJPENDO.00253.2003

21 January 2018

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12959935