Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development (Q80827612)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15467748%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

title

Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15467748%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

1 reference

Christine M Eischen

1

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3 January 2020

Jodi R Alt

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15467748%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

Peng Wang

series ordinal

3

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3 January 2020

publication date

1 November 2004

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3 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15467748%20AND%20SRC:MED&resulttype=core&format=json

3 January 2020

volume

23

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3 January 2020

issue

55

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3 January 2020

page(s)

8931-8940

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208052

3 January 2020

exact match

0 references

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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ARF function does not require p53 stabilization or Mdm2 relocalization

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The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

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Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

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mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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