TNF receptor associated factor 2 (Q7671245)

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mammalian protein found in Homo sapiens
  • tumor necrosis factor type 2 receptor associated protein 3
  • E3 ubiquitin-protein ligase TRAF2
  • TRAF2
  • Tumor necrosis factor type 2 receptor-associated protein 3
  • TNF receptor-associated factor 2
  • RING-type E3 ubiquitin transferase TRAF2
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Language Label Description Also known as
English
TNF receptor associated factor 2
mammalian protein found in Homo sapiens
  • tumor necrosis factor type 2 receptor associated protein 3
  • E3 ubiquitin-protein ligase TRAF2
  • TRAF2
  • Tumor necrosis factor type 2 receptor-associated protein 3
  • TNF receptor-associated factor 2
  • RING-type E3 ubiquitin transferase TRAF2

Statements

molecular function
protein binding
determination method
IPI
49 references
retrieved
1 January 2018
stated in
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Asymmetric recruitment of cIAPs by TRAF2
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
TRAF family proteins link PKR with NF-kappa B activation
GOA
curator
UniProt
UniProt protein ID
Q12933
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Protein interactions of the transcription factor Hoxa1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Rotavirus NSP1 inhibits interferon induced non-canonical NFκB activation by interacting with TNF receptor associated factor 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Unconventional ligand activation of herpesvirus entry mediator signals cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
OTUB1 modulates c-IAP1 stability to regulate signalling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
retrieved
1 January 2018
stated in
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE TRAF2 204413 at fs.png
732 × 530; 11 KB
0 references

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q7671245&oldid=2022910540"