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TNF receptor associated factor 2 (Q7671245)

From Wikidata
mammalian protein found in Homo sapiens
  • tumor necrosis factor type 2 receptor associated protein 3
  • E3 ubiquitin-protein ligase TRAF2
  • TRAF2
  • Tumor necrosis factor type 2 receptor-associated protein 3
  • TNF receptor-associated factor 2
  • RING-type E3 ubiquitin transferase TRAF2
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    English
    TNF receptor associated factor 2
    mammalian protein found in Homo sapiens
    • tumor necrosis factor type 2 receptor associated protein 3
    • E3 ubiquitin-protein ligase TRAF2
    • TRAF2
    • Tumor necrosis factor type 2 receptor-associated protein 3
    • TNF receptor-associated factor 2
    • RING-type E3 ubiquitin transferase TRAF2

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    49 references
    retrieved
    1 January 2018
    stated in
    TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Asymmetric recruitment of cIAPs by TRAF2
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    TRAF family proteins link PKR with NF-kappa B activation
    GOA
    curator
    UniProt
    UniProt protein ID
    Q12933
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    FBXO7 Y52C polymorphism as a potential protective factor in Parkinson's disease
    GOA
    curator
    Parkinsons Disease Gene Ontology Initiative
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Protein interactions of the transcription factor Hoxa1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A proteome-scale map of the human interactome network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The MEKK 1 PHD ubiquitinates TAB 1 to activate MAPK s in response to cytokines
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signalling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    T2BP, a novel TRAF2 binding protein, can activate NF-kappaB and AP-1 without TNF stimulation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Rotavirus NSP1 inhibits interferon induced non-canonical NFκB activation by interacting with TNF receptor associated factor 2
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Towards a proteome-scale map of the human protein–protein interaction network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Unconventional ligand activation of herpesvirus entry mediator signals cell survival
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    OTUB1 modulates c-IAP1 stability to regulate signalling pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Widespread macromolecular interaction perturbations in human genetic disorders
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Network organization of the human autophagy system
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    Next-generation sequencing to generate interactome datasets
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    retrieved
    1 January 2018
    stated in
    The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12933
    determination method or standard
    IPI
    cell component
    biological process
    Gene Atlas image
    PBB GE TRAF2 204413 at fs.png
    732 × 530; 11 KB
    0 references

    Identifiers

    PDB structure ID
     
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                      Retrieved from "https://www.wikidata.org/w/index.php?title=Q7671245&oldid=2022910540"