Bone morphogenetic protein 4 (Q700001)

http://www.ebi.ac.uk/interpro/protein/P12644

Cystine-knot cytokine

1 reference

stated in

InterPro Release 66.0

http://www.ebi.ac.uk/interpro/protein/P12644

1 reference

11 May 2017

1 reference

11 May 2017

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

1 reference

27 March 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

transforming growth factor beta receptor binding

IPI

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

1 reference

27 March 2018

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

7 references

27 March 2018

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

Agrin binds BMP2, BMP4 and TGFbeta1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

IPI

chemoattractant activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

proteinaceous extracellular matrix

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

27 March 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

endoplasmic reticulum lumen

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

embryonic skeletal system morphogenesis

TAS

biological process

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

negative regulation of T cell differentiation in thymus

1 reference

27 March 2018

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

IMP

germ cell development

1 reference

27 March 2018

skeletal system development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

mesenchymal cell differentiation involved in renal system development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

cardiac septum development

1 reference

27 March 2018

Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

positive regulation of endothelial cell differentiation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

negative regulation of immature T cell proliferation in thymus

1 reference

27 March 2018

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

bud elongation involved in lung branching

IMP

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

anatomical structure formation involved in morphogenesis

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

negative regulation of cell cycle

1 reference

27 March 2018

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

mesenchymal to epithelial transition involved in metanephros morphogenesis

1 reference

27 March 2018

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

1 reference

27 March 2018

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

monocyte differentiation

1 reference

27 March 2018

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

27 March 2018

BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

cranial suture morphogenesis

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

Involvement of FGF and BMP family proteins and VEGF in early human kidney development

mesonephros development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

odontogenesis of dentin-containing tooth

IEP

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

telencephalon regionalization

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

negative regulation of chondrocyte differentiation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

blood vessel development

1 reference

27 March 2018

negative regulation of mitotic nuclear division

1 reference

27 March 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

prostate gland morphogenesis

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

positive regulation of ERK1 and ERK2 cascade

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

BMP signaling pathway involved in heart induction

1 reference

27 March 2018

BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

negative regulation of epithelial cell proliferation

IMP

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

inner ear receptor cell differentiation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

mesodermal cell fate determination

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

metanephros development

1 reference

27 March 2018

type B pancreatic cell development

1 reference

27 March 2018

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

regulation of pathway-restricted SMAD protein phosphorylation

1 reference

27 March 2018

BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

negative regulation of cell proliferation

2 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644