The expression and function of PAX3 in development and disease. (Q65666079)

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Bishwanath Chatterjee

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Wenyue Sun

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Prasantha Vemu

Splotch locus mouse mutants: models for neural tube defects and Waardenburg syndrome type I in humans

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language of work or name

English

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publication date

5 August 2018

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published in

Gene

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volume

666

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page(s)

145-157

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cites work

1 reference

12 December 2020

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

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Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

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Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro

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Chromosomal analysis of sixteen human rhabdomyosarcomas

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12 December 2020

A specific chromosomal abnormality in rhabdomyosarcoma.

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12 December 2020

Consistent chromosomal translocation in alveolar rhabdomyosarcoma

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12 December 2020

Previously undescribed syndrome of craniofacial, hand anomalies, and sensorineural deafness

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12 December 2020

Alveolar rhabdomyosarcoma: a cytogenetic and correlated cytological and histological study

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12 December 2020

Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes

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12 December 2020

Pax3: A paired domain gene as a regulator in PNS myelination

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12 December 2020

Identification of DNA recognition sequences for the Pax3 paired domain

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12 December 2020

Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification.

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12 December 2020

Regulation of Pax-3 expression in the dermomyotome and its role in muscle development.

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12 December 2020

Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

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12 December 2020

Wild type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains

1 reference

12 December 2020

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

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12 December 2020

Initial steps of myogenesis in somites are independent of influence from axial structures.

1 reference

12 December 2020

Pax3 inhibits myogenic differentiation of cultured myoblast cells

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12 December 2020

Pax-3 contains domains for transcription activation and transcription inhibition

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12 December 2020

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

1 reference

12 December 2020

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12 December 2020

Cooperative dimerization of paired class homeo domains on DNA.

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12 December 2020

Molecular basis of splotch and Waardenburg Pax-3 mutations

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12 December 2020

Pax: genes for mice and men.

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12 December 2020

Locus heterogeneity for Waardenburg syndrome is predictive of clinical subtypes.

1 reference

12 December 2020

Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains.

1 reference

12 December 2020

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1 reference

12 December 2020

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1 reference

12 December 2020

Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes

1 reference

12 December 2020

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

1 reference

12 December 2020

The Splotch mutation interferes with muscle development in the limbs

1 reference

12 December 2020

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1 reference

12 December 2020

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1 reference

12 December 2020

Mutations in the paired domain of the human PAX3 gene cause Klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I)

1 reference

12 December 2020

Mutations in PAX3 that cause Waardenburg syndrome type I: ten new mutations and review of the literature

1 reference

12 December 2020

The mutational spectrum in Waardenburg syndrome.

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12 December 2020

Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse

1 reference

12 December 2020

Pax3 modulates expression of the c-Met receptor during limb muscle development

1 reference

12 December 2020

Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma

1 reference

12 December 2020

Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma

1 reference

12 December 2020

Missense mutation in the paired domain of PAX3 causes craniofacial-deafness-hand syndrome

1 reference

12 December 2020

Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice.

1 reference

12 December 2020

An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity.

1 reference

12 December 2020

Positive and negative DNA sequence elements are required to establish the pattern of Pax3 expression.

1 reference

12 December 2020

Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD.

1 reference

12 December 2020

The paired-domain regulates DNA binding by the homeodomain within the intact Pax-3 protein

1 reference

12 December 2020

Expression of PAX3 in Ewing's sarcoma family of tumors

1 reference

12 December 2020

Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma

1 reference

12 December 2020

Interaction of the pRB-family proteins with factors containing paired-like homeodomains

1 reference

12 December 2020

Epistatic relationship between Waardenburg syndrome genes MITF and PAX3

1 reference

12 December 2020

Structural analysis of PAX3 genomic rearrangements in alveolar rhabdomyosarcoma

1 reference

12 December 2020

Septo-optic dysplasia and WS1 in the proband of a WS1 family segregating for a novel mutation in PAX3 exon 7.

1 reference

12 December 2020

Normal and rearranged PAX3 expression in human rhabdomyosarcoma

1 reference

12 December 2020

Identification of a new binding motif for the paired domain of Pax-3 and unusual characteristics of spacing of bipartite recognition elements on binding and transcription activation

1 reference

12 December 2020

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

1 reference

12 December 2020

A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors.

1 reference

12 December 2020

The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain.

1 reference

12 December 2020

Pax3 functions in cell survival and in pax7 regulation

1 reference

12 December 2020

Fine-scale transgenic mapping of the MyoD core enhancer: MyoD is regulated by distinct but overlapping mechanisms in myotomal and non-myotomal muscle lineages

1 reference

12 December 2020

The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx

1 reference

12 December 2020

Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects

1 reference

12 December 2020

PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma

1 reference

12 December 2020

Pax3 and Regulation of the Melanocyte-specific Tyrosinase-related Protein-1 Promoter

1 reference

12 December 2020

PAX3 gene structure, alternative splicing and evolution

1 reference

12 December 2020

Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines.

1 reference

12 December 2020

The birth of muscle progenitor cells in the mouse: spatiotemporal considerations

1 reference

12 December 2020

PAX3 is expressed in human melanomas and contributes to tumor cell survival

1 reference

12 December 2020

Transcription factors in melanocyte development: distinct roles for Pax-3 and Mitf.

1 reference

12 December 2020

PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma

1 reference

12 December 2020

Microarray analysis detects novel Pax3 downstream target genes

1 reference

12 December 2020

Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma

1 reference

12 December 2020

Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis

1 reference

12 December 2020

The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3

1 reference

12 December 2020

Induction of the neural crest: a multigene process

1 reference

12 December 2020

Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions

1 reference

12 December 2020

CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.

1 reference

12 December 2020

The formation of skeletal muscle: from somite to limb

1 reference

12 December 2020

Alternative splicing of Pax3 produces a transcriptionally inactive protein

1 reference

12 December 2020

Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer

1 reference

12 December 2020

Expression of PAX 3 alternatively spliced transcripts and identification of two new isoforms in human tumors of neural crest origin

1 reference

12 December 2020

A new syndrome combining developmental anomalies of the eyelids, eyebrows and nose root with pigmentary defects of the iris and head hair and with congenital deafness

1 reference

12 December 2020

Divergent functions of murine Pax3 and Pax7 in limb muscle development

1 reference

12 December 2020

Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression

1 reference

12 December 2020

Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo

1 reference

12 December 2020

Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.

1 reference

12 December 2020

Systematic identification of human melanoma antigens using serial analysis of gene expression (SAGE).

1 reference

12 December 2020

Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.

1 reference

12 December 2020

Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction.

1 reference

12 December 2020

Pax3 functions at a nodal point in melanocyte stem cell differentiation

1 reference

12 December 2020

Identification of a hypaxial somite enhancer element regulating Pax3 expression in migrating myoblasts and characterization of hypaxial muscle Cre transgenic mice

1 reference

12 December 2020

Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin-induced cytotoxicity

1 reference

12 December 2020

Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation.

1 reference

12 December 2020

Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein

1 reference

12 December 2020

Transcriptional activity of Pax3 is co-activated by TAZ

1 reference

12 December 2020

Pax3 transcripts in melanoblast development

1 reference

12 December 2020

Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells.

1 reference

12 December 2020

Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas

1 reference

12 December 2020

Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1.

1 reference

12 December 2020

Functional analysis of alternative isoforms of the transcription factor PAX3 in melanocytes in vitro

1 reference

12 December 2020

A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb

1 reference

12 December 2020

Investigation of downstream target genes of PAX3c, PAX3e and PAX3g isoforms in melanocytes by microarray analysis

1 reference

12 December 2020

Cooperative interactions between the two DNA binding domains of Pax3: helix 2 of the paired domain is in the proximity of the amino terminus of the homeodomain

1 reference

12 December 2020

The role of Pax genes in the development of tissues and organs: Pax3 and Pax7 regulate muscle progenitor cell functions

1 reference

12 December 2020

Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR

1 reference

12 December 2020

Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors

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12 December 2020

PAX-FKHR function as pangenes by simultaneously inducing and inhibiting myogenesis

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12 December 2020

Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma

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12 December 2020

Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities.

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12 December 2020

Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program

1 reference

12 December 2020

PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype

1 reference

12 December 2020

Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma

1 reference

12 December 2020

Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression.

1 reference

12 December 2020

High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts

1 reference

12 December 2020

Phosphorylation of serine 205 by the protein kinase CK2 persists on Pax3-FOXO1, but not Pax3, throughout early myogenic differentiation

1 reference

12 December 2020

Recurrent t(2;2) and t(2;8) translocations in rhabdomyosarcoma without the canonical PAX-FOXO1 fuse PAX3 to members of the nuclear receptor transcriptional coactivator family

1 reference

12 December 2020

Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions

1 reference

12 December 2020

PAX3 and SOX10 activate MET receptor expression in melanoma

1 reference

12 December 2020

PAX3 Is extensively expressed in benign and malignant tissues of the melanocytic lineage in humans

1 reference

12 December 2020

Review and update of mutations causing Waardenburg syndrome.

1 reference

12 December 2020

Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer

1 reference

12 December 2020

PAX3 mutations and clinical characteristics in Chinese patients with Waardenburg syndrome type 1

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12 December 2020

MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3

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12 December 2020

Taf1 regulates Pax3 protein by monoubiquitination in skeletal muscle progenitors

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12 December 2020

Role of Pax3 acetylation in the regulation of Hes1 and Neurog2.

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12 December 2020

Identification of serines 201 and 209 as sites of Pax3 phosphorylation and the altered phosphorylation status of Pax3-FOXO1 during early myogenic differentiation

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12 December 2020

MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis

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12 December 2020

Pitx2c modulates Pax3+/Pax7+ cell populations and regulates Pax3 expression by repressing miR27 expression during myogenesis.

1 reference

12 December 2020

PAX3-FOXO1 induces cannabinoid receptor 1 to enhance cell invasion and metastasis.

1 reference

12 December 2020

Dual embryonic origin of the mammalian otic vesicle forming the inner ear.

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12 December 2020

Pax3 stimulates p53 ubiquitination and degradation independent of transcription

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12 December 2020

Clinical significance and prognostic value of PAX3 expression in human glioma.

1 reference

12 December 2020

Low-grade sinonasal sarcoma with neural and myogenic features: a clinicopathologic analysis of 28 cases

1 reference

12 December 2020

Neural crest induction at the neural plate border in vertebrates

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12 December 2020

Alternative polyadenylation mediates microRNA regulation of muscle stem cell function

1 reference

12 December 2020

Genomic and clinical analysis of fusion gene amplification in rhabdomyosarcoma: a report from the Children's Oncology Group

1 reference

12 December 2020

1 reference

12 December 2020

Identification of a novel microRNA that regulates the proliferation and differentiation in muscle side population cells

1 reference

12 December 2020

Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs

1 reference

12 December 2020

GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells

1 reference

12 December 2020

Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells.

1 reference

12 December 2020

Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism

1 reference

12 December 2020

A transcription factor–based mechanism for mouse heterochromatin formation

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12 December 2020

Identification of CK2 as the kinase that phosphorylates Pax3 at Ser209 in early myogenic differentiation

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12 December 2020

JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells.

1 reference

12 December 2020

PAX3 is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells

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12 December 2020

Mutationmapper: a tool to aid the mapping of protein mutation data

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12 December 2020

Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer

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12 December 2020

Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube

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12 December 2020

Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors

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12 December 2020

Immunohistochemical expression of homeoproteins Six1 and Pax3 in breast phyllodes tumours correlates with histological grade and clinical outcome.

1 reference

12 December 2020

Pax3 function is required specifically for inner ear structures with melanogenic fates.

1 reference

12 December 2020

Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma

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12 December 2020

Phosphorylation of PAX3 contributes to melanoma phenotypes by affecting proliferation, invasion, and transformation

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12 December 2020

Lineage of origin in rhabdomyosarcoma informs pharmacological response

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12 December 2020

Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest

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12 December 2020

PAX3 and ETS1 synergistically activate MET expression in melanoma cells

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12 December 2020

Activation of PAX3-MET pathways due to miR-206 loss promotes gastric cancer metastasis

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12 December 2020

Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options

1 reference

12 December 2020

Identification of a Novel De Novo Variant in the PAX3 Gene in Waardenburg Syndrome by Diagnostic Exome Sequencing: The First Molecular Diagnosis in Korea

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12 December 2020

Loading of PAX3 to Mitotic Chromosomes Is Mediated by Arginine Methylation and Associated with Waardenburg Syndrome

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12 December 2020

PAX3 and FOXD3 Promote CXCR4 Expression in Melanoma

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12 December 2020

A novel mutation in the PAX3 gene causes Waardenburg syndrome type I in an Iranian family.

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12 December 2020

The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth

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12 December 2020

Alternate PAX3-FOXO1 oncogenic fusion in biphenotypic sinonasal sarcoma

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12 December 2020

Novel PAX3-NCOA1 Fusions in Biphenotypic Sinonasal Sarcoma With Focal Rhabdomyoblastic Differentiation

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12 December 2020

A novel mutation in PAX3 associated with Waardenburg syndrome type I in a Chinese family

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12 December 2020

Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion

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12 December 2020

Fusion gene profile of biphenotypic sinonasal sarcoma: an analysis of 44 cases.

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12 December 2020

Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects

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12 December 2020

Loss of MicroRNA-489-3p promotes osteosarcoma metastasis by activating PAX3-MET pathway.

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12 December 2020

PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma

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12 December 2020

PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability.

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12 December 2020

Acquisition of an oncogenic fusion protein is sufficient to globally alter the landscape of miRNA expression to inhibit myogenic differentiation

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12 December 2020

Germinal mosaicism of PAX3 mutation caused Waardenburg syndrome type I.

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12 December 2020

PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma.

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12 December 2020