p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death (Q64379190)

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4 January 2020

title

p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death (English)

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4 January 2020

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8

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4 January 2020

author name string

Sean P Cregan

1

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4 January 2020

Nicole A Arbour

2

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4 January 2020

Jason G Maclaurin

3

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4 January 2020

Steven M Callaghan

4

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4 January 2020

Andre Fortin

5

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4 January 2020

Eric C C Cheung

6

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4 January 2020

Daniel S Guberman

7

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4 January 2020

Ruth S Slack

9

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language of work or name

English

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publication date

1 November 2004

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4 January 2020

published in

Journal of Neuroscience

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4 January 2020

volume

24

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4 January 2020

page(s)

10003-10012

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4 January 2020

issue

44

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Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

4 January 2020

cites work

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12 December 2020

Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat.

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12 December 2020

Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons

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12 December 2020

HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia.

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12 December 2020

PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

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12 December 2020

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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12 December 2020

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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12 December 2020

Helper-dependent adenovirus vectors: their use as a gene delivery system to neurons

1 reference

12 December 2020

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

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12 December 2020

Definition of the p53 functional domains necessary for inducing apoptosis

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12 December 2020

Essential role for caspase-8 in transcription-independent apoptosis triggered by p53

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12 December 2020

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

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12 December 2020

BH3-Only proteins-essential initiators of apoptotic cell death

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12 December 2020

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

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12 December 2020

Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells

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12 December 2020

Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.

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12 December 2020

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

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12 December 2020

Regulation and function of the p53 tumor suppressor protein

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12 December 2020

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

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12 December 2020

Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage.

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12 December 2020

PUMA induces the rapid apoptosis of colorectal cancer cells

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12 December 2020

PUMA, a novel proapoptotic gene, is induced by p53

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12 December 2020

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

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12 December 2020

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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12 December 2020

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death.

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12 December 2020

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

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12 December 2020

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

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12 December 2020

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

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12 December 2020

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

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12 December 2020

The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.

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12 December 2020

p53 has a direct apoptogenic role at the mitochondria

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12 December 2020

Regulation of p53 responses by post-translational modifications

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12 December 2020

The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions.

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12 December 2020

The Molecular Mechanism of Noxa-induced Mitochondrial Dysfunction in p53-Mediated Cell Death

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12 December 2020

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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12 December 2020

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

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12 December 2020

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

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12 December 2020

Wild-type p53 binds to the TATA-binding protein and represses transcription

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12 December 2020

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

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12 December 2020

Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die.

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12 December 2020

The tumor suppressor p53 inhibits Net, an effector of Ras/extracellular signal-regulated kinase signaling

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12 December 2020

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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12 December 2020

p53 expression in brain after middle cerebral artery occlusion in the rat

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12 December 2020

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

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12 December 2020

Attenuation of p53 expression protects against focal ischemic damage in transgenic mice

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12 December 2020

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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12 December 2020

Mutations of the p53 gene in human functional adrenal neoplasms

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12 December 2020

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression

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12 December 2020

p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's lymphoma cell lines

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12 December 2020

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis

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12 December 2020

Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death.

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12 December 2020

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

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12 December 2020

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

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12 December 2020

BID: a novel BH3 domain-only death agonist

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12 December 2020

Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons

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12 December 2020

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system

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12 December 2020

Wild-type p53 negatively regulates the expression of a microtubule-associated protein

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12 December 2020

Regulation of p53 stability by Mdm2

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12 December 2020

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease.

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12 December 2020

Bax involvement in p53-mediated neuronal cell death

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12 December 2020

P53- and CD95-associated apoptosis in neurodegenerative diseases

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12 December 2020

Hippocampal Myc and p53 expression following transient global ischemia

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12 December 2020

Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death.

1 reference

12 December 2020

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

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12 December 2020

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

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12 December 2020

The potential tumor suppressor p73 differentially regulates cellular p53 target genes

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12 December 2020

10.1523/JNEUROSCI.2114-04.2004

Identifiers

DOI

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4 January 2020

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