STAT3 Interactors as Potential Therapeutic Targets for Cancer Treatment (Q59618020)

12 December 2020

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

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12 December 2020

Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line

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12 December 2020

Specific inhibition of Stat3 signal transduction by PIAS3

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12 December 2020

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

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12 December 2020

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12 December 2020

EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes

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12 December 2020

Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468.

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12 December 2020

14-3-3 proteins: structure, function, and regulation

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12 December 2020

Negative regulation of cytokine signaling pathways

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12 December 2020

The role of STATs in transcriptional control and their impact on cellular function

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12 December 2020

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12 December 2020

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

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12 December 2020

Protein inhibitor of activated STAT3 regulates androgen receptor signaling in prostate carcinoma cells

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12 December 2020

MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production

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12 December 2020

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

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12 December 2020

Tip60 is a cell-type-specific transcriptional regulator

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12 December 2020

A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei

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12 December 2020

Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a

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12 December 2020

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12 December 2020

NF-kappaB in cancer: from innocent bystander to major culprit

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12 December 2020

Progranulin is a mediator of the wound response

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12 December 2020

The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer.

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12 December 2020

STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif

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12 December 2020

Tip60 is a co-repressor for STAT3

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12 December 2020

Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

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12 December 2020

CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle

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12 December 2020

Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.

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12 December 2020

Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells.

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12 December 2020

The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3

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12 December 2020

Regulation of JAK-STAT signalling in the immune system

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12 December 2020

The JAK/STAT signaling pathway

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12 December 2020

Hop: more than an Hsp70/Hsp90 adaptor protein

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12 December 2020

TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3.

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12 December 2020

Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.

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12 December 2020

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation

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12 December 2020

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

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12 December 2020

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation

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12 December 2020

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.

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12 December 2020

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

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12 December 2020

Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.

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12 December 2020

Cancer/testis antigens, gametogenesis and cancer

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12 December 2020

Regulation of gene-activation pathways by PIAS proteins in the immune system

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12 December 2020

Interferons in the treatment of solid tumors

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12 December 2020

EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization.

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12 December 2020

Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements

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12 December 2020

Physical and functional interactions between Daxx and STAT3

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12 December 2020

Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

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12 December 2020

Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA

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12 December 2020

Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages

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12 December 2020

Arl2 and Arl3 regulate different microtubule-dependent processes

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12 December 2020

Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest.

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12 December 2020

BCR-ABL activates STAT3 via JAK and MEK pathways in human cells

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12 December 2020

Overexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation

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12 December 2020

Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx

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12 December 2020

PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit

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12 December 2020

Proteome analysis of hepatocellular carcinoma by two-dimensional difference gel electrophoresis: novel protein markers in hepatocellular carcinoma tissues

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12 December 2020

Physical and functional interactions between STAT3 and KAP1.

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12 December 2020

Crif1 is a novel transcriptional coactivator of STAT3

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12 December 2020

BART is essential for nuclear retention of STAT3

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12 December 2020

Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation

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12 December 2020

An RNA biding protein, Y14 interacts with and modulates STAT3 activation

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12 December 2020

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

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12 December 2020

Epstein-Barr virus-derived EBNA2 regulates STAT3 activation

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12 December 2020

Identification of pancreatic cancer invasion-related proteins by proteomic analysis

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12 December 2020

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

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12 December 2020

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

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12 December 2020

Nuclear protein IkappaB-zeta inhibits the activity of STAT3.

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12 December 2020

PELP1: A novel therapeutic target for hormonal cancers

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12 December 2020

Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer

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12 December 2020

Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification.

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12 December 2020

Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma

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12 December 2020

Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.

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12 December 2020

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

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12 December 2020

The heat shock response: life on the verge of death

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12 December 2020

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

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12 December 2020

RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation

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12 December 2020

Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy

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12 December 2020

Retracted: A Functional Nuclear Epidermal Growth Factor Receptor, Src and Stat3 Heteromeric Complex in Pancreatic Cancer Cells

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12 December 2020

Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients

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12 December 2020

Krüppel-associated box-associated protein 1 negatively regulates TNF-α-induced NF-κB transcriptional activity by influencing the interactions among STAT3, p300, and NF-κB/p65

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12 December 2020

Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy

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12 December 2020

PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3.

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12 December 2020

14-3-3ζ interacts with stat3 and regulates its constitutive activation in multiple myeloma cells

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12 December 2020

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

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12 December 2020

CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

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12 December 2020

Impaired IFN- Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

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12 December 2020

Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma

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12 December 2020

The ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitination

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12 December 2020

The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain

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12 December 2020

Cyclophilin D extramitochondrial signaling controls cell cycle progression and chemokine-directed cell motility.

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12 December 2020

Tumor stress-induced phosphoprotein1 (STIP1) as a prognostic biomarker in ovarian cancer

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12 December 2020

Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics

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12 December 2020

Selective inhibition of tumor oncogenes by disruption of super-enhancers

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12 December 2020

Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity.

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12 December 2020

Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice

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12 December 2020

Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.

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12 December 2020

Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance

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12 December 2020

Therapeutic modulators of STAT signalling for human diseases

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12 December 2020

JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon cancer cells

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12 December 2020

SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma

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12 December 2020

Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727

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12 December 2020

STAT1 and STAT3 in tumorigenesis: A matter of balance.

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12 December 2020

STAT3 regulation by S-nitrosylation: implication for inflammatory disease

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12 December 2020

HIC1 interacts with and modulates the activity of STAT3.

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12 December 2020

Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer

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12 December 2020

Super-enhancers in the control of cell identity and disease

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12 December 2020

EGF receptor trafficking: consequences for signaling and cancer

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12 December 2020

Toward a new STATe: the role of STATs in mitochondrial function

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12 December 2020

Targeting the tumor microenvironment with interferon-β bridges innate and adaptive immune responses.

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12 December 2020

STAT3 and metabolism: how many ways to use a single molecule?

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12 December 2020

Oncogenic protein interfaces: small molecules, big challenges.

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12 December 2020

STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation

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12 December 2020

MAGEC2, an epithelial-mesenchymal transition inducer, is associated with breast cancer metastasis

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12 December 2020

STAT3 Target Genes Relevant to Human Cancers

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12 December 2020

S-Glutathionylation at Cys328 and Cys542 impairs STAT3 phosphorylation.

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12 December 2020

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities

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12 December 2020

What are super-enhancers?

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12 December 2020

Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activate nuclear factor κB (NF-κB) and STAT3 transcription factors for tumorigenesis and tumor maintenance

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12 December 2020

The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

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12 December 2020

STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.

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12 December 2020

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers

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12 December 2020

Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer.

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12 December 2020

Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP

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12 December 2020

STATs: An Old Story, Yet Mesmerizing

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12 December 2020

PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus

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12 December 2020

Mitochondrial Stat3, the Need for Design Thinking

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12 December 2020

Emerging Roles of Epigenetic Regulator Sin3 in Cancer

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12 December 2020

A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.

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12 December 2020

HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancer

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12 December 2020

Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer

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12 December 2020

SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer

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12 December 2020

Mitochondrial STAT3: Powering up a potent factor

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12 December 2020

Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells

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12 December 2020

The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signaling.

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12 December 2020

SIN3A and SIN3B differentially regulate breast cancer metastasis

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12 December 2020

Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation

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12 December 2020

FGFR a promising druggable target in cancer: Molecular biology and new drugs.

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12 December 2020

STAT3 in cancer: A double edged sword

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12 December 2020

Histone Deacetylase Inhibitors as Anticancer Drugs

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12 December 2020

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

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12 December 2020

Lys63-polyubiquitination by the E3 ligase casitas B-lineage lymphoma-b (Cbl-b) modulates peripheral regulatory T cell tolerance in patients with systemic lupus erythematosus.

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12 December 2020

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus.

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12 December 2020