The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers (Q57183712)

1 July 2019

title

The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers (English)

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1 July 2019

author

Ian Dunham

5

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1 July 2019

author name string

Zbyslaw Sondka

1

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1 July 2019

Sally Bamford

2

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1 July 2019

Charlotte G Cole

3

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1 July 2019

Sari A Ward

4

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1 July 2019

Simon A Forbes

6

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1 July 2019

language of work or name

English

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publication date

1 November 2018

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1 July 2019

published in

Nature Reviews Cancer

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1 July 2019

volume

18

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1 July 2019

issue

11

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1 July 2019

page(s)

696-705

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1 July 2019

https://scigraph.springernature.com/pub.10.1038/s41568-018-0060-1

exact match

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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Poly(ADP-ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

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7 January 2021

The Hallmarks of Cancer

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The emerging complexity of gene fusions in cancer

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TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions

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In multiple myeloma, 14q32 translocations are nonrandom chromosomal fusions driving high expression levels of the respective partner genes

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Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma

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The histone acetyltransferase Myst2 regulates Nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells

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MYST2 acetyltransferase expression and Histone H4 Lysine acetylation are suppressed in AML.

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Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

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Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas

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ATM and ATR signaling at a glance

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ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1.

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Mutation and cancer: statistical study of retinoblastoma

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Phosphorylated retinoblastoma protein complexes with pp32 and inhibits pp32-mediated apoptosis

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RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy

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Retinoblastoma protein expression is an independent predictor of both radiation response and survival in muscle-invasive bladder cancer.

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RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis

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Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

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Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells

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Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis

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7 January 2021

Neomorphic mutations create therapeutic challenges in cancer.

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7 January 2021

Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions

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Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase

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7 January 2021

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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7 January 2021

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling

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7 January 2021

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

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Tissue-specific tumorigenesis: context matters

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7 January 2021

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.

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7 January 2021

The significance of dynamin 2 expression for prostate cancer progression, prognostication, and therapeutic targeting.

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7 January 2021

Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1

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Processing of primary microRNAs by the Microprocessor complex

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Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour

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Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

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High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer.

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The Emerging Role of Non-traditional Ubiquitination in Oncogenic Pathways.

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Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-κB-activating potential.

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7 January 2021

ESR1 mutations—a mechanism for acquired endocrine resistance in breast cancer

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7 January 2021

MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells

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7 January 2021

TBLR1 as an androgen receptor (AR) coactivator selectively activates AR target genes to inhibit prostate cancer growth

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7 January 2021

The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes

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7 January 2021

CHD4 in the DNA-damage response and cell cycle progression: not so NuRDy now

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7 January 2021

UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia

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7 January 2021

The H3K27me3 demethylase UTX in normal development and disease

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7 January 2021

TET1 plays an essential oncogenic role in MLL-rearranged leukemia

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7 January 2021

TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway

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7 January 2021

Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression

1 reference

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7 January 2021

The role of corepressors in transcriptional regulation by nuclear hormone receptors

1 reference

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7 January 2021

The SMRT coregulator enhances growth of estrogen receptor-α-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis

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7 January 2021

A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation

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7 January 2021

Hdac3 is essential for the maintenance of chromatin structure and genome stability

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7 January 2021

Alteration of SMRT tumor suppressor function in transformed non-Hodgkin lymphomas

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7 January 2021

The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation

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7 January 2021

The ERCC1 and ERCC4 (XPF) genes and gene products

1 reference

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The human XPG gene: gene architecture, alternative splicing and single nucleotide polymorphisms

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H. pylori-Induced DNA Strand Breaks Are Introduced by Nucleotide Excision Repair Endonucleases and Promote NF-κB Target Gene Expression

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7 January 2021

XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes

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7 January 2021

FOXA1: a transcription factor with parallel functions in development and cancer.

1 reference

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7 January 2021

FoxA1 as a lineage-specific oncogene in luminal type breast cancer

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The mutational landscape of lethal castration-resistant prostate cancer

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Androgen receptor-independent function of FoxA1 in prostate cancer metastasis

1 reference

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7 January 2021

Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer

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7 January 2021

FOXA1 represses the molecular phenotype of basal breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FS41568-018-0060-1

7 January 2021

Wnt signaling in cancer.

1 reference

https://api.crossref.org/works/10.1038%2FS41568-018-0060-1

7 January 2021

Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein

1 reference

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7 January 2021

Fas ligand-induced apoptosis

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7 January 2021

CD95 promotes tumour growth

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7 January 2021

CD95 and CD95L promote and protect cancer stem cells

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7 January 2021

The role of BRCA1 in transcriptional regulation and cell cycle control

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7 January 2021

Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain.

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7 January 2021

Association between cytosolic expression of BRCA1 and metastatic risk in breast cancer.

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Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma

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Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome.

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BubR1 kinase: protection against aneuploidy and premature aging

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DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor

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DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway

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Oncogenic role of DDX3 in breast cancer biogenesis.

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7 January 2021

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

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SPOP promotes tumor progression via activation of β-catenin/TCF4 complex in clear cell renal cell carcinoma

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How cell death shapes cancer

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When dying is not the end: Apoptotic caspases as drivers of proliferation.

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MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

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MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

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BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.

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Structure of the Bcr-Abl oncoprotein oligomerization domain

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BRCA1-IRIS overexpression promotes formation of aggressive breast cancers

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The role of the apoptotic machinery in tumor suppression

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SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering

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Fas Signaling Promotes Gastric Cancer Metastasis through STAT3-Dependent Upregulation of Fascin

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BIRC3 is a novel driver of therapeutic resistance in Glioblastoma

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Nuclear TBLR1 as an ER corepressor promotes cell proliferation, migration and invasion in breast and ovarian cancer

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10.1038/S41568-018-0060-1

Identifiers

DOI

1 reference

1 July 2019

PMCID

6450507

1 reference

1 July 2019

PubMed ID

30293088

1 reference

1 July 2019