Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions (Q24339544)

1

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Chao Wang

2

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Bo Cao

3

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Brett M Hirsch

4

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Jing Song

5

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Sanford D Markowitz

6

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David Sedwick

8

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Lili Liu

9

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Weiping Zheng

10

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Zhenghe Wang

Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T

11

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language of work or name

English

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publication date

13 May 2013

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published in

Cancer Cell

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volume

23

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page(s)

583-93

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issue

5

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cites work

1 reference

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Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion

19 March 2017

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Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T

19 March 2017

1 reference

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Mutations of PIK3CA in gastric adenocarcinoma

19 March 2017

1 reference

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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

19 March 2017

1 reference

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19 March 2017

1 reference

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A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

19 March 2017

1 reference

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Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

19 March 2017

1 reference

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

19 March 2017

1 reference

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The phosphoinositide 3-kinase pathway

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

High frequency of mutations of the PIK3CA gene in human cancers

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Targeting the phosphoinositide 3-kinase pathway in cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

7 April 2017

1 reference

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Structural basis for activation and inhibition of class I phosphoinositide 3-kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Cross-talk between phospho-STAT3 and PLCγ1 plays a critical role in colorectal tumorigenesis

27 September 2017

1 reference

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Translational approaches targeting the p53 pathway for anti-cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Class I PI3K in oncogenic cellular transformation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Structural comparisons of class I phosphoinositide 3-kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Protein-protein interactions as targets for small-molecule therapeutics in cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

The PIK3CA gene is mutated with high frequency in human breast cancers.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3671608

Mutation of the PIK3CA gene in ovarian and breast cancer

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23643389

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2013.03.021

1 reference

652817

652817

1 reference

1 reference

1 reference