New insights into cystic fibrosis: molecular switches that regulate CFTR (Q56680230)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

New insights into cystic fibrosis: molecular switches that regulate CFTR (English)

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William B. Guggino

1

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Bruce A. Stanton

series ordinal

2

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publication date

June 2006

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published in

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volume

7

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page(s)

426-436

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issue

6

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exact match

https://scigraph.springernature.com/pub.10.1038/nrm1949

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cites work

Cystic fibrosis since 1938.

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Increased prevalence of chronic rhinosinusitis in carriers of a cystic fibrosis mutation

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Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers

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Intracellular CFTR: localization and function

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The role of regulated CFTR trafficking in epithelial secretion

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Gating of CFTR by the STAS domain of SLC26 transporters

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Epithelial sodium channels regulate cystic fibrosis transmembrane conductance regulator chloride channels in Xenopus oocytes.

31 March 2020

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Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics

31 March 2020

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Synergistic effects of cystic fibrosis transmembrane conductance regulator and aquaporin-9 in the rat epididymis

31 March 2020

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CFTR drives Na+-nHCO-3 cotransport in pancreatic duct cells: a basis for defective HCO-3 secretion in CF.

31 March 2020

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CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

31 March 2020

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Assembly and Trafficking of a Multiprotein ROMK (Kir 1.1) Channel Complex by PDZ Interactions

31 March 2020

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CFTR pharmacology and its role in intestinal fluid secretion

31 March 2020

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Functional role of anion channels in cardiac diseases

31 March 2020

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Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis

31 March 2020

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New concepts of the pathogenesis of cystic fibrosis lung disease

31 March 2020

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Assembly of functional CFTR chloride channels

31 March 2020

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Role of quality control pathways in human diseases involving protein misfolding

31 March 2020

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PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes

31 March 2020

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The cystic fibrosis transmembrane regulator forms macromolecular complexes with PDZ domain scaffold proteins

31 March 2020

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Macromolecular complexes of cystic fibrosis transmembrane conductance regulator and its interacting partners

31 March 2020

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Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)

31 March 2020

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C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins

31 March 2020

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Beyond the brush border: NHERF4 blazes new NHERF turf

31 March 2020

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E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells

31 March 2020

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An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton

31 March 2020

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Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif

31 March 2020

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Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity

31 March 2020

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The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and epithelia

31 March 2020

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Intermolecular interaction between R domains of cystic fibrosis transmembrane conductance regulator

31 March 2020

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Molecular assembly of cystic fibrosis transmembrane conductance regulator in plasma membrane

31 March 2020

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Purification and crystallization of the cystic fibrosis transmembrane conductance regulator (CFTR).

31 March 2020

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A single conductance pore for chloride ions formed by two cystic fibrosis transmembrane conductance regulator molecules

31 March 2020

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Structural analysis of cloned plasma membrane proteins by freeze-fracture electron microscopy

31 March 2020

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CFTR is a monomer: biochemical and functional evidence

31 March 2020

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Dimeric cystic fibrosis transmembrane conductance regulator exists in the plasma membrane

31 March 2020

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Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel

31 March 2020

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Constitutive internalization of cystic fibrosis transmembrane conductance regulator occurs via clathrin-dependent endocytosis and is regulated by protein phosphorylation

31 March 2020

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PKA holoenzyme is functionally coupled to CFTR by AKAPs

31 March 2020

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Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin

31 March 2020

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A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA

31 March 2020

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Localized effects of cAMP mediated by distinct routes of protein kinase A.

31 March 2020

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The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.

31 March 2020

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Interaction of the protein phosphatase 2A with the regulatory domain of the cystic fibrosis transmembrane conductance regulator channel

31 March 2020

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The roles of PDZ-containing proteins in PLC-beta-mediated signaling.

31 March 2020

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A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactions

31 March 2020

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Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor

31 March 2020

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Role of a PDZ1 domain of NHERF1 in the binding of airway epithelial RACK1 to NHERF1.

31 March 2020

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Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells

31 March 2020

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Stimulation of beta 2-adrenergic receptor increases cystic fibrosis transmembrane conductance regulator expression in human airway epithelial cells through a cAMP/protein kinase A-independent pathway

31 March 2020

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Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions

31 March 2020

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CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex

31 March 2020

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Role of snare proteins in CFTR and ENaC trafficking

31 March 2020

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The interaction between syntaxin 1A and cystic fibrosis transmembrane conductance regulator Cl- channels is mechanistically distinct from syntaxin 1A-SNARE interactions

31 March 2020

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Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms

31 March 2020

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Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.

31 March 2020

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Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase

31 March 2020

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Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells

31 March 2020

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Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism

31 March 2020

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Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation

31 March 2020

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Activation of AMP-activated protein kinase reduces cAMP-mediated epithelial chloride secretion

31 March 2020

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Regulation of plasma membrane recycling by CFTR.

31 March 2020

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Regulated endocytosis in a chloride secretory epithelial cell line

31 March 2020

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Vasoactive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium

31 March 2020

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Epitope tagging permits cell surface detection of functional CFTR.

31 March 2020

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Syntaxin 1A inhibits regulated CFTR trafficking in xenopus oocytes.

31 March 2020

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Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal

31 March 2020

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Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia

31 March 2020

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PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator

31 March 2020

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Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10

31 March 2020

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A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression

31 March 2020

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Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL

31 March 2020

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The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins

31 March 2020

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Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibro

31 March 2020

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Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6

31 March 2020

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Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epithelia

31 March 2020

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PDZ-binding motifs are unable to ensure correct polarized protein distribution in the absence of additional localization signals

31 March 2020

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A PDZ-interacting domain in CFTR is an apical membrane polarization signal

31 March 2020

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The Ras superfamily at a glance

31 March 2020

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Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator

31 March 2020

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Endocytic trafficking routes of wild type and DeltaF508 cystic fibrosis transmembrane conductance regulator

31 March 2020

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The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells

31 March 2020

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Wild type but not deltaF508 CFTR inhibits Na+ conductance when coexpressed in Xenopus oocytes.

31 March 2020

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CFTR as a cAMP-dependent regulator of sodium channels

31 March 2020

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Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function

31 March 2020

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Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50

31 March 2020

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Identification of novel human WW domain-containing proteins by cloning of ligand targets

31 March 2020

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SRC family kinases mediate epithelial Na+ channel inhibition by endothelin

31 March 2020

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Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

31 March 2020

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Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

31 March 2020

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Pharmacological approaches to correcting the ion transport defect in cystic fibrosis

31 March 2020

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S-nitrosoglutathione increases cystic fibrosis transmembrane regulator maturation.

31 March 2020

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Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane regulator reconstitution

31 March 2020

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Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis

31 March 2020

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Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator

31 March 2020

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Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells

31 March 2020

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