Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. (Q33925348)

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6 January 2020

title

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening (English)

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6 January 2020

1

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6 January 2020

Gergely L Lukacs

series ordinal

2

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6 January 2020

Luis Galietta

series ordinal

6

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4

Emanuela Caci

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6 January 2020

5

Olga Zegarra-Moran

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7

A S Verkman

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6 January 2020

author name string

Kai Du

series ordinal

3

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6 January 2020

publication date

25 August 2005

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Journal of Clinical Investigation

6 January 2020

language of work or name

English

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published in

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volume

115

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6 January 2020

issue

9

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6 January 2020

page(s)

2564-2571

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Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis

6 January 2020

cites work

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The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.

5 July 2018

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Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

5 July 2018

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Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy

5 July 2018

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The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator

5 July 2018

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Endocytic trafficking routes of wild type and DeltaF508 cystic fibrosis transmembrane conductance regulator

5 July 2018

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Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes

5 July 2018

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5 July 2018

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Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

5 July 2018

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Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screening

5 July 2018

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Green fluorescent protein-based halide indicators with improved chloride and iodide affinities

5 July 2018

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Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds

5 July 2018

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Conformational and temperature-sensitive stability defects of the delta F508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments.

5 July 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

5 July 2018

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Molecular pharmacology of the CFTR Cl- channel

5 July 2018

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Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms

5 July 2018

1 reference

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Structure and function of the CFTR chloride channel

5 July 2018

1 reference

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In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR

5 July 2018

1 reference

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Delta F508-CFTR channels: kinetics, activation by forskolin, and potentiation by xanthines

5 July 2018

1 reference

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Mechanism of dysfunction of two nucleotide binding domain mutations in cystic fibrosis transmembrane conductance regulator that are associated with pancreatic sufficiency.

5 July 2018

1 reference

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Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP

5 July 2018

1 reference

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The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

5 July 2018

1 reference

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Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

5 July 2018

1 reference

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Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2

5 July 2018

1 reference

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Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

5 July 2018

1 reference

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Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis

5 July 2018

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Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating

5 July 2018

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Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.

29 October 2018

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High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening

29 October 2018

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Role of CFTR in airway disease

29 October 2018

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Biosynthesis and degradation of CFTR.

29 October 2018

1 reference

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Genistein potentiates wild-type and delta F508-CFTR channel activity

29 October 2018

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Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

29 October 2018

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Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins

29 October 2018

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Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

29 October 2018

1 reference

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Processing of CFTR bearing the P574H mutation differs from wild-type and deltaF508-CFTR

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16127463

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An electrogenic amino acid transporter in the apical membrane of cultured human bronchial epithelial cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16127463

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI24898

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16127463%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference

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6 January 2020

PubMed publication ID

16127463

1 reference