Thresholds of replication stress signaling in cancer development and treatment. (Q54538558)

31 May 2018

title

Thresholds of replication stress signaling in cancer development and treatment. (English)

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31 May 2018

3

Jirina Bartkova

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31 May 2018

1

Jiri Bartek

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31 May 2018

Martin Mistrik

2

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31 May 2018

publication date

5 January 2012

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31 May 2018

Nature Structural & Molecular Biology

published in

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31 May 2018

volume

19

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31 May 2018

page(s)

5-7

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31 May 2018

issue

1

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31 May 2018

https://scigraph.springernature.com/pub.10.1038/nsmb.2220

exact match

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cites work

Principles of cancer therapy: oncogene and non-oncogene addiction

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The DNA-damage response in human biology and disease

21 January 2018

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An oncogene-induced DNA damage model for cancer development

21 January 2018

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Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

21 January 2018

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ATR: an essential regulator of genome integrity

21 January 2018

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

21 January 2018

1 reference

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

21 January 2018

1 reference

Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress

21 January 2018

1 reference

Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs

21 January 2018

1 reference

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

21 January 2018

1 reference

Maintaining genome stability at the replication fork

21 January 2018

1 reference

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

21 January 2018

1 reference

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 January 2018

1 reference

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

21 January 2018

1 reference

Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

21 January 2018

1 reference

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

21 January 2018

1 reference

ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

21 January 2018

1 reference

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

21 January 2018

1 reference

DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'.

21 January 2018

1 reference

Replication stress induces 53BP1-containing OPT domains in G1 cells

21 January 2018

1 reference

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

21 January 2018

1 reference

Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

21 January 2018

1 reference

Transcription-coupled repair and apoptosis provide specific protection against transcription-associated mutagenesis by ultraviolet light

21 January 2018

1 reference

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

21 January 2018

1 reference

Transcription and replication: breaking the rules of the road causes genomic instability

21 January 2018

1 reference

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22218289

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22218289

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.2220

1 reference

31 May 2018

Dimensions Publication ID

1005399327

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Fatcat ID

release_cx4xcnmt2nbojjdtcaliz7fdge

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cx4xcnmt2nbojjdtcaliz7fdge

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

22218289

1 reference

31 May 2018