Exosome component 10 (Q5420679)

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mammalian protein found in Homo sapiens

autoantigen PM-SCL
polymyositis/scleroderma autoantigen 2
polymyositis/scleroderma autoantigen 100 kDa
P100 polymyositis-scleroderma overlap syndrome-associated autoantigen
PM/Scl-100
EXOSC10
Autoantigen PM/Scl 2
exosome component 10

Language	Label	Description	Also known as
English	Exosome component 10	mammalian protein found in Homo sapiens	autoantigen PM-SCL polymyositis/scleroderma autoantigen 2 polymyositis/scleroderma autoantigen 100 kDa P100 polymyositis-scleroderma overlap syndrome-associated autoantigen PM/Scl-100 EXOSC10 Autoantigen PM/Scl 2 exosome component 10

Statements

1 reference

13 November 2019

UniProt protein ID

Ribonuclease H-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01780

HRDC-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01780

3'-5' exonuclease domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HRDC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Exosome-associated factor Rrp6, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

exoribonuclease activity

determination method

1 reference

9 May 2019

Reconstitution, activities, and structure of the eukaryotic RNA exosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

protein binding

determination method

10 references

9 May 2019

The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

The RNA helicase DDX5/p68 is a key factor promoting c-fos expression at different levels from transcription to mRNA export

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

A protein interaction framework for human mRNA degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

catalytic activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

3'-5' exonuclease activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nucleic acid binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclease activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

exonuclease activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01780&geneProductId=UniProtKB:Q01780

determination method

26 September 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01780&geneProductId=UniProtKB:Q01780

determination method

26 September 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01780&geneProductId=UniProtKB:Q01780

determination method

3'-5'-exoribonuclease activity

determination method

3 references

8 April 2019

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

8 April 2019

Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

8 April 2019

C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

telomerase RNA binding

determination method

1 reference

9 May 2019

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

3'-5'-exoribonuclease activity

determination method

4 references

9 May 2019

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

single-stranded RNA binding

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

determination method

1 reference

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01780&geneProductId=UniProtKB:Q01780

determination method

nuclear exosome (RNase complex)

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01780&geneProductId=UniProtKB:Q01780

determination method

intracellular anatomical structure

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01780&geneProductId=UniProtKB:Q01780

determination method

determination method

4 references

8 April 2019

Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

8 April 2019

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

determination method

1 reference

9 May 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear exosome (RNase complex)

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

determination method

5 references

9 May 2019

Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

biological process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear polyadenylation-dependent rRNA catabolic process

determination method

1 reference

8 April 2019

Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nucleic acid phosphodiester bond hydrolysis

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

CUT catabolic process

determination method

1 reference

9 May 2019

RNA exosome depletion reveals transcription upstream of active human promoters

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear-transcribed mRNA catabolic process

determination method

1 reference

9 May 2019

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear mRNA surveillance

determination method

1 reference

9 May 2019

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

cell metabolism

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

histone mRNA catabolic process

determination method

1 reference

8 April 2019

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

dosage compensation by inactivation of X chromosome

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nucleobase-containing compound metabolic process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

RNA phosphodiester bond hydrolysis, exonucleolytic

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

negative regulation of telomere maintenance via telomerase

determination method

1 reference

9 May 2019

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

regulation of telomerase RNA localization to Cajal body

determination method

1 reference

9 May 2019

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear polyadenylation-dependent rRNA catabolic process

determination method

nuclear polyadenylation-dependent snoRNA catabolic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear polyadenylation-dependent snRNA catabolic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear polyadenylation-dependent tRNA catabolic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear polyadenylation-dependent CUT catabolic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

nuclear polyadenylation-dependent antisense transcript catabolic process

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

histone mRNA catabolic process

determination method

polyadenylation-dependent snoRNA 3'-end processing

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01780

determination method

Gene Atlas image

PBB GE EXOSC10 207541 s at fs.png
732 × 530; 11 KB

0 references

3'-5' exonuclease domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01780

Exosome-associated factor Rrp6, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01780

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01780

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000307307

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000307307

ENSP00000366135

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000366135

ENSP00000465008

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465008

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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