Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. (Q53613309)

16 May 2018

title

Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. (English)

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16 May 2018

author name string

Xiaoyan Zhong

series ordinal

1

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16 May 2018

Randall N Pittman

series ordinal

2

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16 May 2018

publication date

5 July 2006

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16 May 2018

published in

Human Molecular Genetics

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16 May 2018

volume

15

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16 May 2018

issue

16

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16 May 2018

page(s)

2409-2420

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16 May 2018

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

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The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

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A membrane protein required for dislocation of misfolded proteins from the ER

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A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

21 January 2018

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Ubx2 links the Cdc48 complex to ER-associated protein degradation

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Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

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Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

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Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

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Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

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A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

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AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation

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Retrotranslocation of MHC class I heavy chain from the endoplasmic reticulum to the cytosol is dependent on ATP supply to the ER lumen

21 January 2018

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Quality control in the endoplasmic reticulum protein factory

21 January 2018

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An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.

21 January 2018

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Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

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Ataxin-3 with an altered conformation that exposes the polyglutamine domain is associated with the nuclear matrix

21 January 2018

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21 January 2018

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Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system

21 January 2018

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Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome

21 January 2018

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Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome

21 January 2018

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21 January 2018

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Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDL164

1 reference

16 May 2018

PubMed ID

16822850

1 reference

16 May 2018