A membrane protein required for dislocation of misfolded proteins from the ER (Q24297703)

GOA release 2020-03-11

Derlin 2

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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

GOA release 2020-03-11

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2

Hidde L Ploegh

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author name string

Brendan N Lilley

series ordinal

1

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publication date

24 June 2004

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language of work or name

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429

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issue

6994

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page(s)

834-40

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cites work

1 reference

The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary

20 April 2017

1 reference

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

20 April 2017

1 reference

A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

20 April 2017

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Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

20 April 2017

1 reference

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

20 April 2017

1 reference

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

20 April 2017

1 reference

A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised

20 April 2017

1 reference

Global analysis of protein localization in budding yeast

20 April 2017

1 reference

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

20 April 2017

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The Pfam protein families database

20 April 2017

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Cloning and characterization of F-LANa, upregulated in human liver cancer

20 April 2017

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Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

20 April 2017

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Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p

20 April 2017

1 reference

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

20 April 2017

1 reference

X-ray structure of a protein-conducting channel

20 April 2017

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Quality control in the endoplasmic reticulum

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Ubiquitination Is Required for the Retro-translocation of a Short-lived Luminal Endoplasmic Reticulum Glycoprotein to the Cytosol for Degradation by the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

HRD4/NPL4Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Viral subversion of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

A novel putative transmembrane protein, IZP6, is expressed in neural cells during embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Formation of stacked ER cisternae by low affinity protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

US2, a Human Cytomegalovirus-encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592

One-dimensional isoelectric focusing of proteins in slab gels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02592