NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. (Q53582888)

15 May 2018

title

NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. (English)

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15 May 2018

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6

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Songtao Shi

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object named as

Songtao Shi

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15 May 2018

author name string

Bae Keun Park

1

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15 May 2018

Honglai Zhang

2

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Qinghua Zeng

3

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15 May 2018

Jinlu Dai

4

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15 May 2018

Evan T Keller

5

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Keni Gu

7

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Veena Shah

8

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Lei Pei

9

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Richard J Zarbo

10

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Laurie McCauley

11

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Shaoqiong Chen

13

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Cun-Yu Wang

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language of work or name

English

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publication date

10 December 2006

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15 May 2018

published in

Nature Medicine

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volume

13

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page(s)

62-69

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issue

1

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https://scigraph.springernature.com/pub.10.1038/nm1519

exact match

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cites work

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Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.

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Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy

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Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone

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Critical determinants of metastasis

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Dissemination and growth of cancer cells in metastatic sites

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Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis

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NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

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A multigenic program mediating breast cancer metastasis to bone

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Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

21 January 2018

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TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

21 January 2018

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Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

21 January 2018

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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

21 January 2018

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Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells.

21 January 2018

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Breast tumor cell lines from pleural effusions

21 January 2018

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

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Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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Crosstalk between cancer cells and bone microenvironment in bone metastasis

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Regulation of cancer cell migration and bone metastasis by RANKL.

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GM-CSF in inflammation and autoimmunity.

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Osteoclastic potential of human CFU-GM: biphasic effect of GM-CSF.

21 January 2018

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Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures

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Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation

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Inflammation and cancer

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The Hallmarks of Cancer

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Genomic analysis of metastasis reveals an essential role for RhoC

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Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo.

21 January 2018

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I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

21 January 2018

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Breast cancer cells induce osteoclast formation by stimulating host IL-11 production and downregulating granulocyte/macrophage colony-stimulating factor

21 January 2018

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Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression

21 January 2018

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Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression

21 January 2018

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NF-kappaB in cancer: a marked target

21 January 2018

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Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

21 January 2018

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NF-kappaB regulation in the immune system

21 January 2018

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Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

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Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling

21 January 2018

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Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB

21 January 2018

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7 January 2021

Effects of human recombinant CSF-GM and highly purified CSF-1 on the formation of multinucleated cells with osteoclast characteristics in long-term bone marrow cultures

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7 January 2021

Annexin II stimulates RANKL expression through MAPK

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7 January 2021

Metastasis gets site specific

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7 January 2021

Identifiers

DOI

10.1038/NM1519

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15 May 2018

PubMed ID

17159986

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15 May 2018