Akt2: a critical regulator of cardiomyocyte survival and metabolism. (Q52607535)

4 May 2018

title

Akt2: a critical regulator of cardiomyocyte survival and metabolism. (English)

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4 May 2018

author name string

Anthony J Muslin

series ordinal

1

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4 May 2018

publication date

30 January 2011

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4 May 2018

published in

Pediatric Cardiology

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4 May 2018

volume

32

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4 May 2018

issue

3

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4 May 2018

page(s)

317-322

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4 May 2018

https://scigraph.springernature.com/pub.10.1007/s00246-010-9879-2

exact match

0 references

cites work

TRB3 function in cardiac endoplasmic reticulum stress.

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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Regulation of cell death protease caspase-9 by phosphorylation

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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Beginning to end: cardiovascular implications of growth hormone (GH) deficiency and GH therapy

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Akt2 regulates cardiac metabolism and cardiomyocyte survival

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

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Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway

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Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

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Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

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The role of FOXO in the regulation of metabolism.

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The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

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The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

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Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

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Ventricular hypertrophy and hypertension: prognostic elements and implications for management

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Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.

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The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

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Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure

21 January 2018

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Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

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TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

21 January 2018

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Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions

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TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism

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Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function

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Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells

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Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

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21 January 2018

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ER stress in adipocytes inhibits insulin signaling, represses lipolysis, and alters the secretion of adipokines without inhibiting glucose transport.

21 January 2018

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Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

21 January 2018

1 reference

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A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus

21 January 2018

1 reference

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E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3

21 January 2018

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Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy

21 January 2018

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12 December 2020

Akt1 is required for physiological cardiac growth

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12 December 2020

Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments

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12 December 2020

Role of Akt in cardiac growth and metabolism

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12 December 2020

The unfolded protein response

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12 December 2020

10.1007/S00246-010-9879-2

Identifiers

DOI

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4 May 2018

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4 May 2018