Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils (Q40591759)

21 September 2017

Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils (English)

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21 September 2017

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David A Hildeman

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Philippa Marrack

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Philippa Marrack

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author name string

Shyra J Gardai

1

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21 September 2017

Steve K Frankel

3

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21 September 2017

Ben B Whitlock

4

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21 September 2017

S Courtney Frasch

5

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21 September 2017

Niels Borregaard

6

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21 September 2017

Donna L Bratton

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21 September 2017

Peter M Henson

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21 September 2017

language of work or name

English

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publication date

6 February 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

21085-21095

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21 September 2017

20

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To die or not to die: an overview of apoptosis and its role in disease.

21 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Granulocyte apoptosis and its role in the resolution and control of lung inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

21 January 2018

The Bcl-2 protein family

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8, and 9 during endothelial cell apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Bax directly induces release of cytochrome c from isolated mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Purification and biochemical properties of soluble recombinant human Bax.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Cellular survival: a play in three Akts

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Phosphatidylinositol 3-kinase signaling to Akt mediates survival in isolated canine islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

CREB is a regulatory target for the protein kinase Akt/PKB

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Heterogeneity in the phosphorylation of human death receptors by p42(mapk/erk2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Interleukin-5 inhibits translocation of Bax to the mitochondria, cytochrome c release, and activation of caspases in human eosinophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Subcellular fractionation of human neutrophils on Percoll density gradients.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Inhibition of TNF-alpha-induced neutrophil apoptosis by crystals of calcium pyrophosphate dihydrate is mediated by the extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways up-stream of caspase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Molecular control of neutrophil apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M400063200

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M400063200

21 January 2018

Identifiers

DOI

10.1074/JBC.M400063200

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21 September 2017

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