Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function (Q24294552)

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

BCL-2 family members and the mitochondria in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Direct addition of BimL to mitochondria does not lead to cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Smad3 potentiates transforming growth factor beta (TGFbeta )-induced apoptosis and expression of the BH3-only protein Bim in WEHI 231 B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI-3B is due to retroviral insertion near the gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Ten years of protein kinase B signalling: a hard Akt to follow

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Identification of a DEF-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the BH3-only protein BimEL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Protein kinase C theta and epsilon promote T-cell survival by a rsk-dependent phosphorylation and inactivation of BAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

7 January 2021

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

7 January 2021

Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

7 January 2021

BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

7 January 2021

14-3-3 inhibits Bad-induced cell death through interaction with serine-136

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505546200

7 January 2021