Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. (Q51873528)

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27 January 2020

title

Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice (English)

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author name string

Tatsuya Hoshino

1

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27 January 2020

Naoya Murao

2

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27 January 2020

Takushi Namba

3

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27 January 2020

Masaya Takehara

4

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27 January 2020

Masahisa Katsuno

6

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27 January 2020

Takahide Matsushima

8

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27 January 2020

Toshiharu Suzuki

9

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27 January 2020

Tohru Mizushima

10

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Gen Sobue

7

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language of work or name

English

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publication date

1 April 2011

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27 January 2020

published in

Journal of Neuroscience

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volume

31

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27 January 2020

page(s)

5225-5234

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issue

14

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Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene.

27 January 2020

cites work

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12 December 2020

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

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Single oral dose of geranylgeranylacetone induces heat-shock protein 72 and renders protection against ischemia/reperfusion injury in rat heart

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

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Age-dependent cognitive decline in the APP23 model precedes amyloid deposition.

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Prostaglandin E2 protects gastric mucosal cells from apoptosis via EP2 and EP4 receptor activation

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Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

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Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

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Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

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Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

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Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

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Pathways towards and away from Alzheimer's disease

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Celastrols as inducers of the heat shock response and cytoprotection.

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Heat shock protein 70 confers cardiovascular protection during endotoxemia via inhibition of nuclear factor-kappaB activation and inducible nitric oxide synthase expression in the rostral ventrolateral medulla

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Modulation of neurodegeneration by molecular chaperones

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Paeoniflorin, a novel heat shock protein-inducing compound

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Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death

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Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect

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Geranylgeranylacetone protects mice from dextran sulfate sodium-induced colitis.

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Heat shock response inhibits NF-kappaB activation and cytokine production in murine Kupffer cells.

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Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

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Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease.

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Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

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12 December 2020

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

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12 December 2020

Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

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12 December 2020

Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides.

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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12 December 2020

CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.

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12 December 2020

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

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12 December 2020

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

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12 December 2020

Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis

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12 December 2020

The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages

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12 December 2020

Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

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12 December 2020

Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo

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12 December 2020

Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease

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12 December 2020

The blood-brain barrier in health and chronic neurodegenerative disorders

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Abeta-degrading enzymes in Alzheimer's disease.

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Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

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Amyloid oligomer conformation in a group of natively folded proteins

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X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain

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Astroglia in dementia and Alzheimer's disease.

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12 December 2020

Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.

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12 December 2020

A role for HSP70 in protecting against indomethacin-induced gastric lesions

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12 December 2020

HSP70 confers protection against indomethacin-induced lesions of the small intestine.

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12 December 2020

Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

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12 December 2020

Prevention of UVB radiation-induced epidermal damage by expression of heat shock protein 70.

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12 December 2020

Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis

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12 December 2020

HSP70 inducers from Chinese herbs and their effect on melanin production

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12 December 2020

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery

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12 December 2020

Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa

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12 December 2020

Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury

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12 December 2020

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

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12 December 2020

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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12 December 2020

Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that int

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12 December 2020

The regulatory role of heat shock protein 70-reactive CD4+ T cells during rat listeriosis

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12 December 2020

A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site.

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12 December 2020

Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection

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12 December 2020

10.1523/JNEUROSCI.5478-10.2011

Identifiers

DOI

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