Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus. (Q51866669)

14 April 2018

title

Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus. (English)

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14 April 2018

author

Andrew J Murphy

12

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author name string

Fabienne Billiard

1

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Jessica R Kirshner

2

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Michelle Tait

3

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Amanda Danave

4

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Sean Taheri

5

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Wen Zhang

6

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Janelle C Waite

7

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Kara Olson

8

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Guoying Chen

9

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Sandra Coetzee

10

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Donna Hylton

11

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George D Yancopoulos

13

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Gavin Thurston

14

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Dimitris Skokos

15

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language of work or name

English

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publication date

4 July 2011

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European Journal of Immunology

published in

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volume

41

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page(s)

2207-2216

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issue

8

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Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.

cites work

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Delta-like 4 is indispensable in thymic environment specific for T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Insights into thymic aging and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Chronic DLL4 blockade induces vascular neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

Notch signaling in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

inferred from DOI database lookup

7 January 2021

based on heuristic

The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

inferred from DOI database lookup

7 January 2021

based on heuristic

Thymopoiesis independent of common lymphoid progenitors

1 reference

https://api.crossref.org/works/10.1002%2FEJI.201041343

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1002/EJI.201041343

1 reference

14 April 2018

PubMed ID

21598246

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14 April 2018