Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells. (Q51796573)

12 April 2018

title

Amplification of the gene for SCAP, coupled with Insig-1 deficiency, confers sterol resistance in mutant Chinese hamster ovary cells. (English)

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12 April 2018

author name string

Peter C W Lee

1

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12 April 2018

Pingsheng Liu

2

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12 April 2018

Wei-Ping Li

3

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12 April 2018

Russell A Debose-Boyd

4

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12 April 2018

publication date

22 June 2007

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12 April 2018

Journal of Lipid Research

published in

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volume

48

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12 April 2018

issue

9

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page(s)

1944-1954

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12 April 2018

Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

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Regulation of the mevalonate pathway

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Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase

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Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain

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Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulum

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Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

21 January 2018

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Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

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Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation

21 January 2018

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Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

21 January 2018

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Three different rearrangements in a single intron truncate sterol regulatory element binding protein-2 and produce sterol-resistant phenotype in three cell lines. Role of introns in protein evolution

21 January 2018

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Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic

21 January 2018

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Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c

21 January 2018

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Caveolin, cholesterol, and lipid bodies

21 January 2018

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Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 January 2018

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21 January 2018

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Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

21 January 2018

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Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells.

21 January 2018

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19 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1016/S0021-9258(19)84879-2

Identifiers

DOI

10.1194/JLR.M700225-JLR200

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12 April 2018

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12 April 2018