The sterol-sensing domain: multiple families, a unique role? (Q34121980)

31 July 2017

title

The sterol-sensing domain: multiple families, a unique role? (English)

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31 July 2017

main subject

Dispatched Dmel_CG2019

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GOA release 2020-03-11

author name string

Patricia E Kuwabara

series ordinal

1

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31 July 2017

Michel Labouesse

series ordinal

2

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31 July 2017

publication date

1 April 2002

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31 July 2017

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31 July 2017

volume

18

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31 July 2017

issue

4

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31 July 2017

page(s)

193-201

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publication type of scholarly work

31 July 2017

review article

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Intracellular cholesterol transport.

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Lipid rafts and signal transduction

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

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Regulation of the mevalonate pathway

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Mutations in the human DHCR7 gene

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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

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Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

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Hedgehog signaling in animal development: paradigms and principles

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7 January 2021

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

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7 January 2021

Functional rafts in cell membranes

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7 January 2021

Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme

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7 January 2021

Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi

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7 January 2021

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi

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7 January 2021

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

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SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

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Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

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7 January 2021

Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

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7 January 2021

Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum

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7 January 2021

Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

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7 January 2021

The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo

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7 January 2021

Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos

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Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes

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Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol

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7 January 2021

Niemann-Pick C1 disease: correlations between NPC1 mutations, levels of NPC1 protein, and phenotypes emphasize the functional significance of the putative sterol-sensing domain and of the cysteine-rich luminal loop

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7 January 2021

Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network

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7 January 2021

Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease

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7 January 2021

Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events

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7 January 2021

Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles

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7 January 2021

Multidrug permeases and subcellular cholesterol transport

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7 January 2021

Transmembrane molecular pump activity of Niemann-Pick C1 protein

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7 January 2021

A model for niemann-pick type C disease in the nematode Caenorhabditis elegans

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7 January 2021

Dual roles for patched in sequestering and transducing Hedgehog

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7 January 2021

A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube

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7 January 2021

Cholesterol modification of hedgehog signaling proteins in animal development

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7 January 2021

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog

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7 January 2021

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

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7 January 2021

Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan

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7 January 2021

A freely diffusible form of Sonic hedgehog mediates long-range signalling

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7 January 2021

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

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7 January 2021

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

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7 January 2021

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

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7 January 2021

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

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Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

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7 January 2021

Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

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7 January 2021

In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration

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7 January 2021

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

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7 January 2021

Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system

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7 January 2021

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein

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7 January 2021

Patched1 interacts with cyclin B1 to regulate cell cycle progression

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7 January 2021

Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains

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7 January 2021

The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane

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7 January 2021

Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

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7 January 2021

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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7 January 2021

Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport

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7 January 2021

Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis

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7 January 2021

Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex

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7 January 2021

Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization

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7 January 2021

CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells

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7 January 2021

Genome sequence of the nematode C. elegans: a platform for investigating biology

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7 January 2021

Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles

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7 January 2021

Mobilization of late-endosomal cholesterol is inhibited by Rab guanine nucleotide dissociation inhibitor

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7 January 2021

Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway

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7 January 2021

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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7 January 2021

How proteins move lipids and lipids move proteins.

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7 January 2021

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Identifiers

DOI

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31 July 2017

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